Human Vasodilatory Effect of GLP-1

Not Applicable

Completed

• Conditions: Coronary Stenosis; Angina, Stable; Type2 Diabetes

• Registration Number: NCT03502083
• Lead Sponsor: Papworth Hospital NHS Foundation Trust

Brief Summary

Comprehensive assessment of human vasodilatory effect of GLP-1 in forearm and coronary arteries

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12-01
• Primary Completion: 2017-03-01
• Study Completion: 2017-03-01
• Status Verified: 2018-04
• Study First Submitted: 2018-04-03
• Study First Submitted QC: 2018-04-10
• Last Update Submitted: 2018-04-10
• Study First Posted: 2018-04-18
• Last Update Posted: 2018-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Waiting list for elective PCI to LAD Able to give informed consent Over 18

Exclusion Criteria

• GLP-1 based therapy Insulin Calcium channel blockers Nicorandil Nitrates

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Forearm bloodflow ratio with GLP-1	Change from baseline	Peripheral vasodilatory response of GLP-1
Change in IMR (index of microcirculatory resistance) with GLP-1 compared with baseline	Change from baseline	Change in coronary microcirculatory resistance from baseline