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临床试验/CTRI/2025/02/079942
CTRI/2025/02/079942尚未招募不适用

Ultrasonographic Evaluation of Positive End-Expiratory Pressure–induced Lung Recruitment: Comparison with the Recruitment-to-Inflation Ratio

Dr G Akhila1 个研究点 分布在 1 个国家目标入组 27 人开始时间: 2025年2月12日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
27
试验地点
1
主要终点
To evaluate the efficacy of lung ultrasonography in assessing lung recruitability and determining the

研究概览

简要总结

Application of an optimal level of positive end-expiratory pressure (PEEP) is a crucial facet of optimizing mechanical ventilation among hypoxic patients. PEEP titration is usually guided by improvement in oxygenation and increase in the static compliance. The ARDSNet table recommends PEEP levels based on the FiO2 requirement. There are drawbacks associated with these methods of PEEP titration. The PaO2 levels may rise with an increase in the PEEP level due to reduced right-left shunt in the lung, unrelated to the extent of recruitment. Besides, alveolar recruitment may not always lead to improved lung compliance. Ultrasonography enables direct visualization of the extent of lung recruitment on application of incremental levels of PEEP. However, hyperinflation of the relatively normal lung cannot be identified by ultrasonography. The recruitment to inflation ration (R/I) evaluates lung compliance at a high and a low level of PEEP and compares the lung compliance at both levels. The R/I ratio may be a predictor of hyperinflation in the relatively normal lung.

Patients with acute hypoxemic respiratory failure with potentially recruitable lungs on mechanical ventilation in the MICU. Its Prospective observational study and aim of the study is to Evaluate the efficacy of bedside lung ultrasonography to assess lung recruitment – correlate with the Recruitment/Inflation (R/I) ratio as a technique to identify hyperinflation of normal lungs.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 99.00 Year(s)(—)
性别
All

入选标准

  • ARDS by Berlin criteria
  • Pulmonary oedema
  • Lung collapse
  • Lung consolidation.

排除标准

  • Hemodynamic instability, with the use of norepinephrine more than 0.2 mcg/kg/min or an equivalent dose of other vasoactive agents (epinephrine more than 0.2 mcg/kg/min, dopamine more than 5 mcg/kg/min, vasopressin more than 0.01 units/min)
  • Decompensated heart failure
  • Raised intracranial pressure (ICP)
  • Presence of pneumothorax
  • Chronic obstructive pulmonary disease
  • Emphysematous lung
  • Patients on end-of-life care 8.

结局指标

主要结局

To evaluate the efficacy of lung ultrasonography in assessing lung recruitability and determining the

时间窗: Baseline

optimal PEEP (Positive End-Expiratory Pressure) settings based on recruitment assessment.

时间窗: Baseline

次要结局

  • To correlate regional lung recruitment assessed through ultrasonography with the Recruitment/Inflation (R/I) ratio and use both techniques to identify hyperinflation, aiming to optimize PEEP levels in mechanically ventilated patients with severe hypoxia.(Baseline)

研究者

发起方
Dr G Akhila
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr G Akhila

Narayana Health

研究点 (1)

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