Viscoelastic Properties of Respiratory and Peripheral Muscles of COPD Patients

Completed

• Conditions: COPD; Muscle Tone Abnormalities

• Registration Number: NCT06580353
• Lead Sponsor: Gaziantep Islam Science and Technology University

Brief Summary

The aim of this study was to compare the viscoelastic properties of auxiliary respiratory muscles and peripheral muscles of chronic obstructive pulmonary disease patients with healthy subjects. Myotonometry was used to evaluate the viscoelastic properties of the muscles. The viscoelastic properties of the sternoclaidus mastoid, pectoralis major, upper trapezius, deltoid, biceps brachii, rectus femoris, gastrocinemius, and tibialis anterior muscles were evaluated.

Detailed Description

muscle viscoelastic properties; muscle tone, stiffness and elasticity. These features may vary due to muscle overuse, lack of relaxation and recovery. The aim is to investigate these differences in COPD patients and healthy individuals.

Study Timeline

• Status Verified: 2024-01
• Study Start: 2024-01-01
• Primary Completion: 2024-04-01
• Study Completion: 2024-05-01
• Study First Submitted: 2024-08-26
• Study First Submitted QC: 2024-08-28
• Study First Posted: 2024-08-30
• Last Update Submitted: 2024-11-21
• Last Update Posted: 2024-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• male gender,
• body mass index (BMI) between 18.5-29.9 kg/m2,
• stable COPD patients

Exclusion Criteria

• being in the acute exacerbation period for COPD patients,
• having undergone any neurological, orthopaedic or thoracic surgery,
• presence of malignancy in any organ,
• presence of comorbidities affecting muscle atrophy (myasthenia gravis, muscular dystrophy, etc.).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Respiratory functions (PEF)	1 Day	Peak expiratory flow (PEF) were measured was evaluated with spirometry. It will be recorded as liters and expected percentage
The Medical Research Council Scale	1 Day	Patients simply indicate on the scale the level of activity that causes dyspnoea in them according to the activities between 0-4.
The COPD Assessment Test	1 Day	This statement describes a scale consisting of eight items, each with response values ranging from 0 to 5. The total score is calculated by summing the responses to all the items, resulting in a range from 0 to 40. A higher total score indicates a greater negative impact of the disease on the individual's quality of life and daily activities.
Viscoelastic properties of muscles	1 Day	The viscoelastic properties of the muscles (muscle tone (Hz), and elasticity (Relative), stiffness (N/m)) were measured using a hand-held myotonometer.
Respiratory functions (FEV1)	1 Day	In pulmonary function test was evaluated with spirometry. forced expiratory volume in the first second (FEV1);will be recorded as liters and expected percentage
Respiratory functions (FVC)	1 Day	In pulmonary function test was evaluated with spirometry. forced expiratory volume in the first second (FEV1);will be recorded as liters and expected percentage
Respiratory functions (FEV1/FVC)	1 Day	ratio of forced expiratory volume in the first second to vital capacity (FEV1/FVC) was evaluated with spirometry.

Trial Locations

Locations (1)

Gaziantep İslamic Science and Technology University; 🇹🇷 Gaziantep, Şahinbey, Turkey