The effects of H1-blockade on activity of neural circuitry associated with psychomotor performance as assessed with the BOLD response
Completed
- Conditions
- n.v.t. gaat om onderzoek bij gezonde vrijwilligersn.v.t.
- Registration Number
- NL-OMON31461
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Males and females
Age 18-45
Good phsyical health as determioned by a medical history questionnaire, medical screening by a physician, ECG and blood haematology
Absence of any medical, endocrine and neurological condition
Body mass index (weight/length2) between 18 and 28 kg/m2
Blood pressure between 100-150 Hg systolic and 60-90 diastolic.
Written informed consent
Exclusion Criteria
History of or current drug abuse
Current use of psychoactive medicinal treatment
Drinking more than 20 alcoholic consumptions per week
For females: pragnancy or lactation
Drinking more than 5 cups of caffeinated drinks per day
Smoking more than 5 cigarettes per day
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are indicators of perceptual-motor performance and<br /><br>brain activity as measured with a subcritical tracking task and choice reaction<br /><br>time task in the MRI scanner (fMRI). Dependent variables are tracking error,<br /><br>reaction time and BOLD response</p><br>
- Secondary Outcome Measures
Name Time Method <p>Subjective alertness</p><br>