Specific and non-specific effects of an H1-antagonist on cognitive information processing
Completed
- Conditions
- gezonde vrijwilligersnvt
- Registration Number
- NL-OMON29987
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 18
Inclusion Criteria
Males and females
Age 18-45
Good physical health as determined by a medical history questionnaire, medical screening by a physician, ECG and blood haematology
Absence of any medical, endocrine and neurological condition
Body mass index (weight/length2) between 18 and 28 kg/m2
Blood pressure between 100-150 Hg systolic and 60-90 Hg diastolic
Written informed consent
Exclusion Criteria
History of or current drug abuse
Current use of psychoactive medicinal treatment
Drinking more than 20 alcoholic consumptions per week
For females: pregnancy or lactation
Drinking more than 5 cups of caffeinated drinks per day
Smoking more than 5 cigarettes per day
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Reaction time in milliseconds as measured by the choice reaction time task,<br /><br>n-back memory task and word recognition task. The number of memorized words<br /><br>during the immediate recall phase and during the delayed recall (few minutes)<br /><br>phase (45 minutes). Number of correct detected letters in the n-back task.<br /><br>Average deviation from midline as measured by the sub-critical tracking task.<br /><br>The different ERP components: N100/P100, N200/P200, P300, CNV and LRP.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>