Etude des effets d’un antagoniste non spécifique de l’endothéline (le bosentan) sur l’activité orthosympathique et le chémoréflexe.
- Conditions
- healthy subjectsobstructive sleep apnea(Bosentan is used in clinic in pulmonary hypertension)
- Registration Number
- EUCTR2006-003133-33-BE
- Lead Sponsor
- Hôpital Erasme
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
healthy male subjects: aged between 18 and 65 years, no medication
male patients with obstructive sleep apnea (hypopnea/apnea index > 30) aged between 18 and 65 years
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
diabetes
alcohol abuse
cyclosporin use
glyburide use
hepatic disease
women
age
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: show if endothelin plays an important role in the control of ventilation in healthy subjects and obstructive sleep apnea patients.;Secondary Objective: better understanding of chemoreflex;Primary end point(s): dicrease in peripheric chemoreflex sensibility
- Secondary Outcome Measures
Name Time Method