The effect of dexamethasone on blood glucose concentrations in diabetic and non diabetic surgical patients
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Patients with and without Diabetes mellitus posted for elective surgery
- Registration Number
- CTRI/2017/03/008150
- Lead Sponsor
- M S Ramaiah Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 180
Inclusion Criteria
1 Age between 18-70 years
2 American Society of Anaesthesiologists (ASA) Grade I or II.
3 Patients with weight >=50kg
4 Patients undergoing lower extremities and infra umbilical surgeries under spinal anaesthesia.
5 Pre operative GRBS between 80 - 180 mg %
Exclusion Criteria
1.Recent IV or oral steroid therapy within last 48 hours
2.Allergy to dexamethasone
3. Conversion to General anaesthesia
4.Body mass index >35
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The outcome of the study is to observe blood glucose concentrations after placebo and 4 or 8mg of dexamethasone in non-diabetic and type 2 diabetic patients undergoing routine surgery under spinal anaesthesia.Timepoint: Finger prick capillary blood glucose will be measured immediately before <br/ ><br>dexamethasone administration (T0) and at 60 minutes (T1), 120 minutes (T2), 180 minutes (T3), 240 minutes <br/ ><br>(T4), 360 minutes (T5) and 480 minutes(T6) thereafter using a glucometer
- Secondary Outcome Measures
Name Time Method Incidence of postoperative nausea and vomiting following Dexamethasone 4mg/8mg compared to placeboTimepoint: Finger prick capillary blood glucose will be measured immediately before dexamethasone administration (T0) and at 60 (T1), 120 (T2), 180 (T3), 240 (T4), 360 (T5) and 480 minutes(T6) thereafter using a glucometer.