NCT02912520已完成不适用
Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- IgA levels in the bronchoalveolar lavage fluid
研究概览
简要总结
Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •endotracheal intubation
- •antibiotic therapy for 2 weeks OR no antibiotic therapy for at least 3 months
排除标准
- •active infection
- •pregnancy
- •immunodeficiency
研究组 & 干预措施
Patients with antibiotic therapy
Patients with antibiotic therapy for 2 weeks.
干预措施: Anti-Bacterial Agents (Drug)
结局指标
主要结局
IgA levels in the bronchoalveolar lavage fluid
时间窗: 2 weeks of ICU stay
次要结局
- number of detected bacterial, viral, and fungal infections per patient(through study completion, an average of 2 months)
研究者
Oliver Robak
MD
Medical University of Vienna
研究点 (1)
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