Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy

Completed

• Conditions: Immunoglobulin A
• Interventions: Drug: Anti-Bacterial Agents

• Registration Number: NCT02912520
• Lead Sponsor: Medical University of Vienna

Brief Summary

Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-09-13
• Study First Submitted QC: 2016-09-20
• Study First Posted: 2016-09-23
• Status Verified: 2017-04
• Primary Completion: 2017-04-23
• Study Completion: 2017-04-23
• Last Update Submitted: 2017-04-23
• Last Update Posted: 2017-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• endotracheal intubation
• antibiotic therapy for 2 weeks OR no antibiotic therapy for at least 3 months

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Exclusion Criteria

• active infection
• pregnancy
• immunodeficiency

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with antibiotic therapy	Anti-Bacterial Agents	Patients with antibiotic therapy for 2 weeks.

Primary Outcome Measures

Name	Time	Method
IgA levels in the bronchoalveolar lavage fluid	2 weeks of ICU stay

Secondary Outcome Measures

Name	Time	Method
number of detected bacterial, viral, and fungal infections per patient	through study completion, an average of 2 months

Trial Locations

Locations (1)

Medical University of Vienna; 🇦🇹 Vienna, Austria