NCT03980015已完成不适用
Inflammatory Responses in Borrelia Afzelii Culture Positive Patients With Early Disseminated or Early Localized Lyme Borreliosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- inflammatory proteins in erythema migrans patients
研究概览
简要总结
The investigators will evaluate differences in host immune responses (levels of cytokines and chemokines, representative of innate, Th1, and Th17 immune responses) in acute sera from adult patients with solitary or multiple erythema migrans.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •erythema migrans in patients > 18 years
- •Borrelia afzelii isolated from skin
排除标准
- •pregnancy or immunocompromising conditions
- •taking antibiotic with antiborrelial activity within 10 days
结局指标
主要结局
inflammatory proteins in erythema migrans patients
时间窗: at enrollment
The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses in serum of patients at enrollment (during active infection).
次要结局
未报告次要终点
研究者
Daša Stupica
Prinicipal Investigator
University Medical Centre Ljubljana
研究点 (1)
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