Application of Physiological Magnetic Resonance Imaging to Study the Relationship between Subchondral Bone Lesions and Cartilage Degeneration and Intervention Study of Yangxue Rougan Decoctio

Phase 1

• Conditions: osteoarthritis

• Registration Number: ITMCTR2100004375
• Lead Sponsor: Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

1. Knee joint pain (pain for more than ten days occurred at least twice in the past year);
2. Imaging standards (K-L grade 0 grade I or grade II, of which K-L grade II only includes osteophyte formation);
3. MRI indicators: MRI found any 2 of the following 4 items:
(1) Cartilage morphology WORMS score of 3-6 points;
(2) Cartilage BLOKS score 2, 3;
(3) Meniscus BLOKS score 3, 4;
(4) Bone marrow edema WORMS score 2, 3 points.

Exclusion Criteria

1. Patients with severe primary diseases such as cardiovascular, liver, kidney and hematopoietic system;
2. There are arthritic diseases such as rheumatoid arthritis and gouty arthritis, and other diseases that affect lower limb function;
3. People with allergies or allergies to multiple drugs;
4. Oral, intramuscular, joint injection or soft tissue injection of glucocorticoid within one month;
5. Long-term use of other drugs that affect the efficacy and safety determination and comprehensive treatment;
6. Those who are not suitable for MRI examination.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
T2 values;