A magnetic resonance and histological investigation of articular cartilage damage in early stage degenerative disease of the hip joint and evaluation of synthetic labro-chondral graft implantatio
- Conditions
- Topic: MusculoskeletalSubtopic: Musculoskeletal (all Subtopics)Disease: Non-inflammatory Joint DisordersMusculoskeletal Diseases
- Registration Number
- ISRCTN01688855
- Lead Sponsor
- St George's University of London (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 45
1. History of hip pain.
2. Tönnis grade 0 or 1 radiographic changes.
3. Hip Joint Space Width (JSW) > 2 mm.
4. Arthroscopic confirmation of:
4.1. Labro-chondral split
4.2. Chondral defect grade 3 and 4 (Outerbridge, ICRS & UCL Classifications)
4.3. Chondral defect size range 0.5 ? 4.0 cm2.
5. Ability to provide informed written consent.
Target Gender: Male & Female; Upper Age Limit 55 years ; Lower Age Limit 18 years
1. OA Grade > 1 (Tönnis scale)
2. Inflammatory joint disease
3. Previous dislocation or fracture of the affected hip
4. Previous non-arthroscopic surgery to the affected hip
5. History of back pain
6. Age <18 years and > 55 years
7. BMI > 30
8. Hip joint space = 2 mm
9. Previous hip joint sepsis or osteomyelitis
10. Metabolic bone disease
11. Osteoporosis
12. Avascular necrosis
13. Associated neurological disease
14. Diabetes
15. Pregnancy
16. Chronic use of narcotics or oral steroids
17. Heavy alcohol intake on a regular basis
18. Inability to give consent or cooperate with the study protocol
19. Non-English speaking patients
20. Patients who move outside United Kingdom
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method tbc; Timepoint(s): tbc
- Secondary Outcome Measures
Name Time Method ot provided at time of registration