Markers of Aggressive Local Therapy In Newly diagnosed Glioblastomas
- Conditions
- GlioblastomasCancerMalignant neoplasm of brain
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 145
1. Imaging appearances of a high grade glioma
2. Likely to be suitable for radiotherapy (60 Gy) with concomitant and adjuvant temozolomide
3. World Health Organization (WHO) performance status (PS) grade 0 or 2
4. Aged 18 - 75 years, either sex
5. Resection or biopsy (although only those suitable for maximal resection will be considered for the MALTING Trial)
Patients for the MALTING Trial will be felt by their consultant neurosurgeon to be suitable for 5-aminolevulinic acid (5-ALA) fluorescence-guided resection with insertion of carmustine wafers.
1. Unsuitable for a contrast-enhanced MRI (MR unsafe metallic implants, claustrophobia, allergy to gadolinium contrast agent or severe renal impairment)
2. Pregnant
3. Allergic to aminolevulinic acid
4. Suffering from porphyria. Care will be taken if the patient is taking other photosensitising drugs.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pattern of contrast enhancement at first recurrence. This will be assessed by co-registering anatomical MR's at recurrence with pre-RT and highlighting areas of new contrast enhancement. Invasive GBM's will be defined as radiological evidence of > 80% of the recurrent tumour occurring outside the radiotherapy 95% isodose. For the MALTING study, the percentage of patients surviving 2 years will be the main outcome measure.
- Secondary Outcome Measures
Name Time Method