Exercise Training in Chagas Cardiomyopathy
Phase 4
Completed
- Conditions
- Chagas DiseaseCardiomyopathyExercise Training
- Interventions
- Other: Exercise training
- Registration Number
- NCT01006473
- Lead Sponsor
- Federal University of Minas Gerais
- Brief Summary
The benefits of exercise training in heart failure are well established. Its effects, however, have not been evaluated in Chagas cardiomyopathy (ChC). The investigators hypothesis is that the exercise training may improve functional capacity, quality of life (QoL), and reduce brain natriuretic peptide (BNP) levels in patients with ChC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 37
Inclusion Criteria
- Chronic Chagas dilated cardiomyopathy, defined by the echocardiography finding of a dilated left ventricle with moderate or severe impaired left ventricular systolic function (left ventricular ejection fraction ≤ 45%).
- To be clinically stable for at least 3 months
- To have sinus rhythm
- To be under standard medical therapy use at the time.
Exclusion Criteria
- Inability to attend regular exercise training
- The presence of a pacemaker, associated cardiac or systemic diseases
- Practitioners of regular physical activity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercise training group Exercise training Exercise training is performed in subgroups of 6 patients supervised by two physiotherapists. Exercise prescription consisted of a 15-min warm-up, walking up to 30 min, followed by a 15-min cooling-down. The exercise intensity during the first 2 weeks corresponds to 55% at 65% of the HR peak reached at the baseline exercise test. In posterior sessions, individual adjustments are performed with gradual increases in order to reach the adequate target HR training intensity, as determined by the Karvonen formula {(maximal HR - HR at rest) x 50 to 70% + HR at rest}. Exercise training is performed in the morning, three times a week (on alternate days) for a total of 12 weeks (36 sessions).
- Primary Outcome Measures
Name Time Method Health related quality of life 12 weeks Functional class 12 weeks Functional capacity 12 weeks BNP levels 12 weeks
- Secondary Outcome Measures
Name Time Method Complications related to the exercise training 12 weeks
Trial Locations
- Locations (1)
Federal University of Minas Gerais
🇧🇷Belo Horizonte, Minas Gerais, Brazil