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Medium-Term Supplementation With Herbal Extract for Exercise Performance and Antioxidant Status

Not Applicable
Completed
Conditions
Exercise Performance
Registration Number
NCT04263246
Lead Sponsor
University of Novi Sad, Faculty of Sport and Physical Education
Brief Summary

We evaluated here the effects of 6-week intervention with herbal supplement on exercise performance outcomes and serum biomarkers of antioxidant status. In addition, we also assessed the long-term effects (6-month) of the intervention in elderly adults.

Detailed Description

Experimental protocol

* Double-blind, randomized, placebo-controlled cross-over trial

* 6-week intervention trial (with additiional follow-up arm after 6 months)

* Experimental intervention (PhytoDyNAmic) = 6 capsules per day

* Placebo (inulin) = 1 g per day b.i.d.

* Administration = 3 capsules with breakfast and 3 capsules with dinner

* Wash-out period = 2 weeks

* No changes in physical activity patterns and diet during the study

Outcomes assessed at baseline and at each follow-up:

* Exercise performance during incremental running-to-exhaustion test

* Serum biomarkers of antioxidant status

* Total antioxidant capacity (TAC)

* Superoxide dismutase (SOD)

* Telomerase activity

Early termination criteria

- Serious subjective side effects of an intervention (e.g. nausea, vomiting, bloating)

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
12
Inclusion Criteria
  • Age ≥ 18 years
  • Body mass index 19 - 25 kg/m2
  • Free of major chronic diseases or acute disorders
Exclusion Criteria
  • Use of dietary supplements within 4 weeks before study commences
  • Unwillingness to return for follow-up analysis

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
Change in time to exhaustionBaseline vs. 6 weeks post-intervention

Baseline vs. 6 weeks

Secondary Outcome Measures
NameTimeMethod
Change in serum total antioxidant capacityBaseline vs. 6 weeks post-intervention

Baseline vs. 6 weeks

Change in serum superoxide dismutaseBaseline vs. 6 weeks post-intervention

Baseline vs. 6 weeks

Change in serum telomerase activityBaseline vs. 6 weeks post-intervention

Baseline vs. 6 weeks

Trial Locations

Locations (1)

Applied Bioenergetics Lab at Faculty of Sport and PE

🇷🇸

Novi Sad, Vojvodina, Serbia

Applied Bioenergetics Lab at Faculty of Sport and PE
🇷🇸Novi Sad, Vojvodina, Serbia

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