Heparin-Binding Protein and Heparins

Completed

• Conditions: Thromboprophylaxis; Vascular Disease, Peripheral; Cardiovascular Diseases
• Interventions: Diagnostic Test: Blood samples for Heparin-binding protein measurement

• Registration Number: NCT04146493
• Lead Sponsor: Halla Halldorsdottir

Brief Summary

Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis. The aim of this study is to find out if Heparins in clinical doses can change the level of Heparin-binding protein in plasma.

Detailed Description

Blood samples are taken from patients before and after Heparins in clinical doses. The effects of heparins on Heparin-binding protein concentration in plasma is measured. This is a small observational study.

Study Timeline

• Study Start: 2019-04-01
• Study First Submitted: 2019-10-23
• Study First Submitted QC: 2019-10-29
• Study First Posted: 2019-10-31
• Primary Completion: 2021-11-30
• Study Completion: 2021-11-30
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-15
• Last Update Posted: 2023-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Planned endovascular treatment of aortic aneurysm or peripheral vascular surgery where unfractionated heparin in >3000 units are given perioperatively
• Planned subcutaneous low molecular weight heparin as a thromboprophylactic treatment after major surgery or on Intensive Care treated patients.
• Planned open heart surgery with cardiopulmonary bypass.

Exclusion Criteria

• Under 18 years
• Unable to get informed consent from patient or relative

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Thromboprophylaxis group	Blood samples for Heparin-binding protein measurement	Patients which are given low molecular heparins as a thrombosprofylax after major surgery
Vascular surgery group	Blood samples for Heparin-binding protein measurement	Patients which are given unfractionated heparin during their vascular surgery.
Cardiothoracic surgery	Blood samples for Heparin-binding protein measurement	Patients which are given high dose unfractionated heparin during their open heart surgey

Primary Outcome Measures

Name	Time	Method
Changes in the level of Heparin-binding protein	Repeated blood sampling during minimum of 1 hour and maximum of 5 hours after given heparin	Blood samples are taken before and after given heparin

Trial Locations

Locations (1)

Halla Halldorsdottir; 🇸🇪 Stockholm, Solna, Sweden