Heparin Binding Protein as a Prognostic Biomarker of Sepsis Severity

Completed

• Conditions: Sepsis; HBP

• Registration Number: NCT05610020
• Lead Sponsor: Ain Shams University

Brief Summary

the aim of the study is to correlate between the severity of sepsis and serum heparin binding protein in the patients admitted to ICU with sepsis., and detect its value as a prognostic biomarker in sepsis

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-01
• Primary Completion: 2022-08-01
• Study Completion: 2022-10-01
• Study First Submitted: 2022-10-20
• Status Verified: 2022-11
• Study First Submitted QC: 2022-11-05
• Last Update Submitted: 2022-11-05
• Study First Posted: 2022-11-08
• Last Update Posted: 2022-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• adult whose age between 20 to70 years old
• patients suffered from sepsis or septic shock (under the third international consensus definition of sepsis and septic shock)

Exclusion Criteria

• Any pregnancy female
• Any patient who is Neutropenic secondary to malignancy
• Patients who is taking immunosuppressive therapy
• Patients who is suffering fromHematological malignancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate the level of Heparin binding protein in relation to patient clinical improvement measured by SOFA Score	72 hours after meeting sepsis ceriteria	Correlates the change of the level of Heparin binding protein in ng/ml to the clinical improvement of the patients which is measured by SOFA score

Secondary Outcome Measures

Name	Time	Method
Heparin binding protein and mortality	28 days after meeting sepsis ceriteria	Correlates the change of the level of Heparin binding protein in ng/ml And how can it is used to predict mortality

Trial Locations

Locations (1)

Omar Hamdy; 🇪🇬 Minya, Egypt