HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis

Completed

• Conditions: Sepsis

• Registration Number: NCT01847248
• Lead Sponsor: Changhai Hospital

Brief Summary

* Molecules indicating endothelial injury may serve as biomarkers for severe sepsis because of the critical role of endothelial injury in organ dysfunction during severe sepsis.

* HSPA12B is primarily located in endothelial cells and detectable during sepsis.

* The investigators speculated that HSPA12B from endothelial cells might be correlated with severe sepsis.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-05
• Primary Completion: 2013-03
• Study First Submitted: 2013-05-02
• Study First Submitted QC: 2013-05-03
• Study First Posted: 2013-05-06
• Study Completion: 2013-10
• Status Verified: 2013-11
• Last Update Submitted: 2013-11-22
• Last Update Posted: 2013-11-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

• Adult patients
• Patients meet the diagnostic criteria according to the grouping

Exclusion Criteria

• patients without informed consent
• patients who were undergoing continuous renal replacement therapy before sampling
• patients with special infection induced by virus, tubercle bacillus, mycoplasma, Chlamydia, and so on

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28-day mortality	28 days	mortality within 28 days after recruitment.

Trial Locations

Locations (1)

Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital; 🇨🇳 Shanghai, China