Sepsis Associated Encephalopathy (SAE) Biomarkers

Recruitment & Eligibility

Status: Active, not recruiting

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria: Cohort 1: - = 18 years old - Presented to the emergency department at Shands - Has not donated blood within the last 8 weeks - Willing to participate and follow up at 6 months after discharge from the hospital - Not anemic or have any other hematological disorders that requires transfusions Meets two or more Systemic Inflammatory Response Syndrome (SIRS) criteria: - Temperature >38°C or <36°C - Heart rate (HR) > 90bpm - Respiratory rate (RR) > 20bpm or partial pressures of carbon dioxide (PaCO2) <32mm mercury (HG) - White Blood Cell (WBC) >12,000/µL or < 4,000/µL or >10% immature/ bands Clinical suspicion of sepsis (blood cultures ordered/ antibiotics started) Altered mental status Enrolled within 6 hours of ED presentation Cohort 2 - = 18 years old - Presented to the emergency department at Shands - Has not donated blood within the last 8 weeks - Willing to participate and follow up at 6 months after discharge from the hospital - Not anemic or have any other hematological disorders that requires transfusions Meets two or more SIRS criteria: - Temperature >38°C or <36°C - HR > 90bpm - RR > 20bpm or PaCO 2 <32mmHG - WBC >12,000/µL or < 4,000/µL or >10% immature/ bands Clinical suspicion of sepsis (blood cultures ordered/ antibiotics started) No altered mental status Enrolled within 6 hours of ED presentation Cohort 3 (control) - Does not meet SIRS criteria - No clinical suspicion of sepsis (no cultures/ antibiotics ordered) - Not altered - Patient has admission orders Exclusion Criteria (all cohorts): - Participating in another interventional, therapeutic study that may affect the results of this study - Subject has neurodegenerative disease or other neurological disorder (dementia, Parkinson's disease, multiple sclerosis, seizure disorder, or brain tumours) - History of neurosurgery within the last 30 days - Acute brain injury within the last 30 days (ischemic/ haemorrhagic stroke, traumatic brain injury) - Subject is anemic OR donated blood within the last 8 weeks OR has a hematological disorder that requires transfusions - Subject has history of liver failure OR renal failure - Pregnant or lactating female

Exclusion Criteria

Not provided

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relationship between biomarkers and neurological outcome- Delirium;Relationship between biomarkers and neurological outcome - Blessed

Secondary Outcome Measures

Name	Time	Method
Relationship between biomarkers and organ dysfunction;Relationship between biomarkers and overall survival;Degree of neurological impairment;Degree of neurological impairment