Non-Cardiac Pulmonary Arterial Hypertension in Infants Presenting with Respiratory Distress: Assessing the Efficacy of Thiamine Supplementation in a Clinical Setting

The project aims to investigate the efficacy of thiamine supplementation in resolving non-cardiac Pulmonary Arterial Hypertension (PAH) in infants with respiratory distress. Conducting a randomized controlled trial (RCT) in Northeast India, where there’s a lack of data, the study seeks to establish a causal relationship between thiamine supplementation and PAH resolution. By addressing confounding factors and measuring thiamine levels, the research aims to influence clinical decision-making, potentially establishing thiamine supplementation as a standard therapeutic approach for non-cardiac PAH in infants, thus improving patient outcomes and care quality.  Our Research hypothesis is that“A significant proportion of infants aged 1month to 12months admitted to our tertiary care hospital presenting with respiratory distress (P) have pulmonary arterial hypertension (PAH) of non-cardiac origin, which have good response to thiamine supplementation (I) leading to a higher rate of resolution of PAH (O) at the end of 72hours (T) within the designated study period compared to infants receiving standard care alone (C).”