Real-time fMRI-based adaptive amygdala neurofeedback using dynamic human facial stimuli to target affective biases in depression

niversity of Zurich0 个研究点目标入组 22 人开始时间: 2022年11月1日最近更新: 2024年1月8日

试验速览

•1. Right-handed adults (18 - 65 years of age) with normal vision.
•2. Primary diagnosis of unipolar depression based on DSM-IV.
•3. Currently in a depressive episode with/without stable SSRI antidepressant medication or oral contraceptives and with/without co-morbid anxiety.
•4. Fluent in German without any intellectual deficits (basic education completed).

•1. Relevant Axis-1disorders: F0 (organic disorders), F1 (alcohol, opioids, etc), F2 (psychotic disorders), bipolar disorder, prominent F4 disorders (i.e., PTSD, Panic disorder), main diagnosis F6 (particularly emotionally unstable personality disorder), known F7 disorder.
•2. Neurological comorbidities such as epilepsy, stroke, brain tumor, and traumatic brain injury based on the MINI Neuropsychiatric assessment.
•3. Patients on antipsychotics, benzodiazepines, medications such as Temesta (>1-2 mg/day), Methadon or Haloperidol except for SSRI antidepressants.
•4. Alcohol, nicotine, or other substance dependence per DSM-IV criteria.
•5. MRI contraindications such as pregnancy, lactation, brain surgery, or metallic implants.

发起方

niversity of Zurich