Patient-Centered Surgical Prehabilitation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 25
- 试验地点
- 4
- 主要终点
- Length of stay
研究概览
简要总结
The purpose of this research is to validate the prehabilitation program which is defined as a set of interventions meant to prepare the body physically and nutritionally for the cystectomy procedure.
详细描述
This research study is testing the efficacy of the prehabilitation study which is a set of investigational interventions and also tries to define the most appropriate and effective set type of interventions to use for further studies. "Investigational" means that the intervention is being studied. In this research study, the investigators hope to learn whether or not this combination of prehabilitation interventions has an impact on the recoverability of participants who will undergo cystectomy or bladder removal surgery. The 5 interventions that make up the prehabilitation study are:
- Participant Interview (If one of the first ten participants)
- Exercise Testing
- Exercise Training
- Nutritional Support
- Clinical Assessment of Nutritional Status
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patents must be candidates for all types of cystectomy surgery including urinary diversion via open or robotic approach.
- •Patients between the ages 18 and 85 years
- •American Society of Anesthesiologists (ASA) Physical Status Score of class 1-4
- •Ileal conduit or ileal neobladder urinary diversion
- •Able to understand the study procedures, agreed to participate in the study program, and voluntarily provided informed consent
排除标准
- •Scheduled for a partial cystectomy
- •Previous total colectomy, gastrectomy, or gastric bypass, or functional colostomy or ileostomy
- •More than three doses of opioids (oral or parenteral) within 7 days before the day of surgery
- •The presence of metastatic cancer
- •Be undergoing treatment for another type of cancer concurrently
- •Chemotherapy for bladder cancer within 1 month of scheduled surgery; prior neoadjuvant chemotherapy allowed.
- •Pregnant (identified by a positive serum pregnancy test administered after the initial screening process and before the commencement of study activities) or lactating, or not postmenopausal (no menses for at least 1 year) and of childbearing potential and not using an accepted method of birth control (i.e, surgical sterilization; intrauterine contraceptive device; oral contraceptive, diaphragm, or condom in combination with contraceptive cream, jelly, or foam; or abstinence) (Participants will be asked to use birth control for the entire study and for at least 2 weeks after the last dose of study drug.)
- •Participated in another investigational drug or medical device study within 30 days of surgery or planning to be enrolled in another investigational drug or medical device study or any study in which active patient participation was required outside normal hospital data collection during the course of this study
- •Clinically significant laboratory abnormalities at screening that would have resulted in the cancellation of surgery
- •Using illicit drugs or abusing alcohol
- •History of previous surgeries, illness, or behavior (eg, depression, psychosis) that in the opinion of the investigator might have confounded the study results or might have posed additional risk in administering the study procedures
- •Patients with severe dementia (as determined from medical records and history. Severe dementia will be defined as dementia that impacts daily functioning.)
- •Patients with severe hepatic impairment as defined by Child-Pugh Class C. Patients with Child-Pugh Class A-B hepatic impairment are eligible for the study.
- •A history of heart failure.
- •Patients with end-stage renal disease as defined by GFR <
- •Patients with heart failure.
- •Patients with complete gastrointestinal obstruction.
- •Patients with gastrostomy tube, jejunostomy tube or who require enteral tube feeds.
- •Non-English-speaking patients
结局指标
主要结局
Length of stay
时间窗: 60 months
This is the total length of stay in days after bladder removal surgery
Number and type of minor and major complications
时间窗: 60 months
This is the number and types of major and minor complications which occur post bladder removal surgery
Total days hospitalized within 30-days of surgery
时间窗: 60 months
This is the total number of days within 30 days after bladder removal surgery, that a patient is hospitalized.
Discharge disposition
时间窗: 60 months
This is the disposition of the patient at discharge or when the patient is released from the hospital.
Readmissions
时间窗: 60 months
This is the number of times a patient that was discharged come back to the hospital for any issue related to their bladder removal surgery.
次要结局
未报告次要终点
研究者
Matthew Mossanen, MD
Urologic Surgeon
Dana-Farber Cancer Institute