Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in AIDS Patients With CD4 Counts = or < 200: A Double-Blind, Placebo-Controlled Trial
- Conditions
- Mycobacterium Avium-intracellulare InfectionHIV Infections
- Registration Number
- NCT00002032
- Lead Sponsor
- Pharmacia
- Brief Summary
The primary objectives of this trial are: To compare the safety of oral rifabutin versus placebo in the treatment of Mycobacterium avium complex (MAC) bacteremia in AIDS patients with CD4 counts less than or equal to 200 cells/mm3. To investigate the incidence of MAC in these patients. A secondary objective is to compare clinical response, quality of life (Karnofsky), and survival between these two groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 750
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (32)
Mem Hosp Hollywood
🇺🇸Hollywood, Florida, United States
AIDS Research Consortium of Atlanta
🇺🇸Atlanta, Georgia, United States
Univ of Texas Southwestern Med Ctr of Dallas
🇺🇸Dallas, Texas, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Houston Clinical Research Network
🇺🇸Houston, Texas, United States
Johns Hopkins School of Medicine
🇺🇸Baltimore, Maryland, United States
Central Texas Med Foundation
🇺🇸Austin, Texas, United States
TheraFirst Med Ctrs Inc
🇺🇸Fort Lauderdale, Florida, United States
Maimonides Med Ctr
🇺🇸Brooklyn, New York, United States
Scott and White Hosp
🇺🇸Temple, Texas, United States
Dr Scott Lea
🇺🇸Waco, Texas, United States
Nelson Tebedo Community Clinic
🇺🇸Dallas, Texas, United States
Ctr for Special Immunology
🇺🇸Fort Lauderdale, Florida, United States
Nassau County Med Ctr
🇺🇸East Meadow, New York, United States
Grady Memorial Hosp / Hughs Spalding Med Ctr
🇺🇸Atlanta, Georgia, United States
Ohio State Univ Med Ctr
🇺🇸Columbus, Ohio, United States
Texas Tech Health Sciences Ctr
🇺🇸El Paso, Texas, United States
Long Island Jewish Med Ctr
🇺🇸New Hyde Park, New York, United States
Community Research Initiative
🇺🇸New York, New York, United States
Olive View Med Ctr
🇺🇸Sylmar, California, United States
CRI of New England
🇺🇸Brookline, Massachusetts, United States
Univ Hosp of Cleveland / Case Western Reserve Univ
🇺🇸Cleveland, Ohio, United States
Chelsea Village Med Ctr
🇺🇸New York, New York, United States
Brooklyn Veterans Administration
🇺🇸Brooklyn, New York, United States
Dr Winkler Weinberg
🇺🇸Roswell, Georgia, United States
Mem Sloan - Kettering Cancer Ctr
🇺🇸New York, New York, United States
Veterans Administration Med Ctr
🇺🇸Washington, District of Columbia, United States
Denver Public Health Dept
🇺🇸Denver, Colorado, United States
VP Med Services / HHCS Research Institute Inc
🇺🇸Orlando, Florida, United States
Univ of Missouri at Kansas City School of Medicine
🇺🇸Kansas City, Missouri, United States
Research Med Ctr
🇺🇸Kansas City, Missouri, United States
Univ TX San Antonio Health Science Ctr
🇺🇸San Antonio, Texas, United States