Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in AIDS Patients With CD4 Counts = or < 200: A Double-Blind, Placebo-Controlled Trial
- Conditions
- Mycobacterium Avium-intracellulare InfectionHIV Infections
- Registration Number
- NCT00002267
- Lead Sponsor
- Pharmacia
- Brief Summary
The primary objective of this trial is to assess the safety and the relative benefit of rifabutin monotherapy in preventing or delaying the incidence of Mycobacterium avium complex (MAC) bacteremia in AIDS patients with CD4 counts less than or equal to 200, as compared to placebo, and to assess if survival is prolonged in patients who receive rifabutin prophylaxis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 750
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (43)
East Bay AIDS Ctr
🇺🇸Berkeley, California, United States
AIDS Community Research Consortium
🇺🇸Redwood City, California, United States
Northwestern Univ Med School
🇺🇸Chicago, Illinois, United States
AIDS Research Alliance - Chicago
🇺🇸Chicago, Illinois, United States
Buckley Braffman Stern Med Associates
🇺🇸Philadelphia, Pennsylvania, United States
HIV Research Group
🇺🇸San Diego, California, United States
Dr Larry A Waites
🇺🇸San Francisco, California, United States
Saint Francis Mem Hosp / HIV Care
🇺🇸San Francisco, California, United States
Dr Marcus Conant
🇺🇸San Francisco, California, United States
San Francisco Veterans Administration Med Ctr
🇺🇸San Francisco, California, United States
Miami Veterans Administration Med Ctr
🇺🇸Miami, Florida, United States
Community Research Initiative of South Florida
🇺🇸Miami, Florida, United States
Univ of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Saint Paul's Hosp
🇨🇦Vancouver, British Columbia, Canada
Maricopa County Med Ctr
🇺🇸Phoenix, Arizona, United States
Comprehensive AIDS Alliance of Detroit / Harper Hosp
🇺🇸Detroit, Michigan, United States
Milwaukee County Med Complex
🇺🇸Milwaukee, Wisconsin, United States
Pacific Oaks Med Group
🇺🇸Beverly Hills, California, United States
North Jersey Community Research Initiative
🇺🇸Newark, New Jersey, United States
AIDS Services Erie County Med Ctr
🇺🇸Buffalo, New York, United States
Dr Marshall Kubota
🇺🇸Santa Rosa, California, United States
Dr Emil Toma / Hotel Dieu de Montreal
🇨🇦Montreal, Quebec, Canada
Albany Veterans Administration
🇺🇸Albany, New York, United States
Mount Sinai Hosp
🇨🇦Toronto, Ontario, Canada
Univ of Calgary Health Science Ctr
🇨🇦Calgary, Alberta, Canada
Thomas Jefferson Med College
🇺🇸Philadelphia, Pennsylvania, United States
McMaster Univ Med Ctr
🇨🇦Hamilton, Ontario, Canada
Ottawa Gen Hosp
🇨🇦Ottawa, Ontario, Canada
Montreal Chest Institute
🇨🇦Montreal, Quebec, Canada
Univ of Alberta/Division of Inf Dis/Dept of Med
🇨🇦Edmonton, Alberta, Canada
Victoria Gen Hosp
🇨🇦Halifax, Nova Scotia, Canada
Dr Jeffrey Galpin
🇺🇸Tarzana, California, United States
St Paul Ramsey Med Ctr
🇺🇸St Paul, Minnesota, United States
Infectious Disease Physicians Inc
🇺🇸Annandale, Virginia, United States
Dr Donald Romig
🇺🇸Sante Fe, New Mexico, United States
Univ of Nevada / Veterans Administration Med Ctr
🇺🇸Reno, Nevada, United States
Saint Michael's Hosp
🇨🇦Toronto, Ontario, Canada
Sunnybrook Health Science Ctr
🇨🇦Toronto, Ontario, Canada
Montreal Gen Hosp
🇨🇦Montreal, Quebec, Canada
Community Health Network
🇺🇸Rochester, New York, United States
Tulane Univ School of Medicine
🇺🇸New Orleans, Louisiana, United States
Dr Alfred F Burnside Jr
🇺🇸Columbia, South Carolina, United States
Univ of New Mexico Hlth Sciences Ctr / Dept of Med
🇺🇸Albuquerque, New Mexico, United States