Swallowing Exercises for Patients With Nasopharyngeal Cancer After Radiation Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Change from Baseline in videofluoroscopic swallowing study (VFSS)
研究概览
简要总结
This study is designed to investigate the treatment efficacy of 8 weeks swallowing exercise programs for patients with NPC after radiation therapy. This study also compares two different swallowing exercise: effortful swallow and Mendelsohn's maneuver, to see which one can bring more benefits to patients after a certain period of exercise training. Three assessment tools are selected to evaluate the study result: Mann Assessment of Swallowing Ability (MASA), videofluoroscopic swallowing study (VFSS), and Chinese version Swallowing Quality-of-Life Questionnaire (CSWAL-QOL). The hypothesis of this study is that the effortful swallowing exercise would have better treatment efficacy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients diagnosed with NPC
- •completed radiation therapy at least 1 year
- •mild to moderate swallowing disorder defined by videofluorography
- •able to comply with protocal mandate, willing to perform the exercise programs, and ability to attend the weekly sessions
排除标准
- •feeding tube insitu
- •received pharyngeal surgery
- •tracheostomy tube insitu
- •patients who could not put effort to push posterior tongue base backward and who could not elevate their pharyngeal during swallowing
- •severe swallowing disorder or aspirate defined by videofluorography
- •other malignances, neurovascular disease, demyelinating disease
- •cancer relapse or metastases
结局指标
主要结局
Change from Baseline in videofluoroscopic swallowing study (VFSS)
时间窗: Change from Baseline in VFSS at 8 weeks
Videofluoroscopic swallowing study (VFSS) measures the bolus transit time including: 1.oral transit time; 2. pharyngeal transit time; and 3. pharyngeal delay time. It also reveals the occurrence of swallowing aspiration or not.
次要结局
- Change from Baseline in Chinese version of the Swallow Quality-of-Life Questionnaire (CSWAL-QOL)(Change from Baseline in CSWAL-QOL at 8 weeks)