ACTRN12606000128594尚未招募不适用
Does habitual low dietary sodium intake augment the response to angiotensin receptor blockade and thiazide therapy in hypertensive patients with type 2 diabetes and elevated albumin excretion rate?
Researcher Initiated Study- Professor George Jerums - Endocrine Centre of Excellence, Austin Health & University of Melbourne0 个研究点目标入组 32 人开始时间: 2006年4月7日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 20 Years 至 80 Years（—）
- 性别
- All
入选标准
- •1. Type 2 diabetes mellitus.2. Hypertension (blood pressure >140/90 or taking antihypertensive therapy).3. Albumin excretion rate > 10 µg/min (median of three consecutive measurements).4. Urinary sodium excretion either > 200 mmole/24 hr on two out of three consecutive occasions (habitual high dietary sodium intake) or < 100 mmole/24 hr on two out of three consecutive occasions (habitual low dietary sodium intake). It is proposed to study 16 patients with habitual high dietary sodium intake and 16 patients with habitual low dietary sodium intake matched for BMI. Matching for BMI will be performed because of the documented association between total caloric intake and urinary sodium excretion in the DASH study.185. Caucasian ethnicity.
排除标准
- •1. Serum potassium > 5.0 mM.2. Serum creatinine > 200 µM.3. Albumin excretion rate > 200 µg/min.4. HbA1C > 10.0%.5. Major systemic illness.6. Drug dependence.7. Atrial fibrillation.8. Lactose intolerance (lactose capsules will be used as placebo).
研究者
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