ACTRN12606000128594
Not yet recruiting
Not Applicable
Does habitual low dietary sodium intake augment the response to angiotensin receptor blockade and thiazide therapy in hypertensive patients with type 2 diabetes and elevated albumin excretion rate?
Researcher Initiated Study- Professor George Jerums - Endocrine Centre of Excellence, Austin Health & University of Melbourne0 sites32 target enrollmentStarted: April 7, 2006Last updated:
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Researcher Initiated Study- Professor George Jerums - Endocrine Centre of Excellence, Austin Health & University of Melbourne
- Enrollment
- 32
Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Treatment
- Masking
- Blinded (masking used)
Eligibility Criteria
- Ages
- 20 Years to 80 Years (—)
- Sex
- All
Inclusion Criteria
- •1\. Type 2 diabetes mellitus.2\. Hypertension (blood pressure \>140/90 or taking antihypertensive therapy).3\. Albumin excretion rate \> 10 µg/min (median of three consecutive measurements).4\. Urinary sodium excretion either \> 200 mmole/24 hr on two out of three consecutive occasions (habitual high dietary sodium intake) or \< 100 mmole/24 hr on two out of three consecutive occasions (habitual low dietary sodium intake). It is proposed to study 16 patients with habitual high dietary sodium intake and 16 patients with habitual low dietary sodium intake matched for BMI. Matching for BMI will be performed because of the documented association between total caloric intake and urinary sodium excretion in the DASH study.185\. Caucasian ethnicity.
Exclusion Criteria
- •1\. Serum potassium \> 5\.0 mM.2\. Serum creatinine \> 200 µM.3\. Albumin excretion rate \> 200 µg/min.4\. HbA1C \> 10\.0%.5\. Major systemic illness.6\. Drug dependence.7\. Atrial fibrillation.8\. Lactose intolerance (lactose capsules will be used as placebo).
Investigators
Similar Trials
Not yet recruiting
Not Applicable
Elevated sodium intake and muscle crampMuscle CrampMusculoskeletal - Other muscular and skeletal disordersACTRN12621000603819niversity of Otago5
Recruiting
Not Applicable
Investigation on the effect of sodium intake and anti-hypertensive therapy in the treatment HypertensioHypertensionJPRN-UMIN000005916Department of Cardiovascular Medicine100
Active, not recruiting
Not Applicable
Can increased sodium intake reduce the risk of exercise associated hyponatraemia ?ACTRN12616000239460School of Physical Education Sport & Exercise Sciences, University of Otago14
Completed
Not Applicable
SALT STUDY: Effect of varying sodium intake and activity on plasma concentrations of N-Terminal BNP in normal subjects and patients with prior Q-wave myocardial infarction (MI)ISRCTN88264942Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)60
Completed
Not Applicable
The effect of increased salt intake with a meal on blood sugar levels in people without diabetes after weight-loss surgeryPrevention of hypoglycaemia in non-diabetic people who have had a gastric bypassNutritional, Metabolic, EndocrineISRCTN12008159niversity of Leicester12