Variability of Acute Response to Equicaloric Test Meals Varying in Glycemic Index and Glycemic Load on Postprandial Glycemia, Arterial Stiffness and Blood Pressure in Healthy Adults
试验速览
- 阶段
- 2 期
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- To measure postprandial changes in augmentation index (AIx) to determine the acute effect of high- and low-GI and high- and low-GL meals on arterial stiffness.
研究概览
简要总结
This study examines the effects of carbohydrate type (high- or low-Glycemic Index (GI)) and amount (high- or low-Glycemic Load (GL)) have on blood glucose levels, blood pressure and arterial stiffness in healthy individuals. It will also determine whether subjective ratings such as test meal palatability and hunger are related to changes in blood glucose. The investigators hypothesize that: (1) High-GI meals, regardless of GL, will increase arterial stiffness; low-GI meals, regardless of GL, will have a neutral or lowering effect on arterial stiffness (augmentation index). (2) High-GI meals, regardless of GL, will have an elevating effect on both central and peripheral blood pressures. (3) The incremental area under the curve for blood glucose will show most significant differences between high-GI, high-GL and low-GI, low-GL meals at 30 and 90 min.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18 - 75 years
- •BMI 18 - 25 kg/m2
- •brachial systolic blood pressure < 140 mmHg
- •brachial diastolic blood pressure < 90 mmHg
排除标准
- •primary hypertension
- •allergy or sensitivity to any foods to be used in the study
- •gastrointestinal disorders
- •chronic kidney disease
- •liver disease
- •hepatitis
- •estrogen-sensitive cancer
- •heavy alcohol use
- •sleep apnea
- •bleeding disorders
- •planned surgery (within time frame of study)
- •Congestive Heart Failure
- •coronary revascularization
- •peripheral vascular disease and/or coronary/cerebrovascular events within the previous 6 months
- •positive HIV diagnosis
- •prescription of anti-depressants, anti-hypertensives, anti-coagulant medications, diuretics, sympathomimetics, herbal therapies, vitamin or K supplementation, medication affecting NO synthesis
- •chronic use or prescription of NSAIDs
- •women of childbearing potential must not be pregnant or breastfeeding
研究组 & 干预措施
Low-GI, High-GL Meal
Boiled Pasta
干预措施: Boiled Pasta (Other)
Low-GI, High GL Meal
Boiled Chickpeas with Oil
干预措施: Boiled Chickpeas with Oil (Other)
High-GI, High-GL Meal
Instant Mashed Potatoes
干预措施: Instant Mashed Potatoes (Other)
High-GI, Low-GL Meal
Instant Mashed Potatoes with Egg Whites
干预措施: Instant Mashed Potatoes with Egg Whites (Other)
结局指标
主要结局
To measure postprandial changes in augmentation index (AIx) to determine the acute effect of high- and low-GI and high- and low-GL meals on arterial stiffness.
时间窗: 4 separate mornings, measurements taken at baseline and at 60, 120, 180 and 240 minutes
次要结局
- To determine the acute effect of high- and low-GI and high- and low- GL meals on central and peripheral blood pressure(4 separate mornings, measurements taken at baseline, 60, 120, 180 and 240 minutes.)