Dutch nOcturnal and hoME dialysis Study To Improve Clinical Outcomes: the prospective study.

Recruiting

Conditions: Chronic Kidney Disease
End Stage Renal Disease
10038430

Registration Number: NL-OMON52673

Lead Sponsor: Amsterdam UMC - Locatie AMC en VUmc

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 2084

Inclusion Criteria

Patient
- Age > 18 years
- Indication to start with RRT
- Willingness to start with a form of RRT

Caregiver
- The subject must care for a partner, family member, friend or a loved one
with end-stage kidney disease that is treated by dialysis therapy and is
included into the DOMESTICO study
- The subject must be 18 years and older

Exclusion Criteria

Patient
- unwillingness to provide informed consent
- life expectancy < 3 months
- expected renal transplantation < 3 months
- unable to fill in questionnaires (including active cognitive disease, active
psychiatric disorder or language barrier other than the languages provided)

Caregiver
- Caregivers who do not provide informed consent

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- To compare quality of life between patients on home dialysis - both PD and<br /><br>home (nocturnal) HD - and patients treated with conventional in-centre HD.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To compare standard clinical outcome parameters (blood pressure, haemoglobin<br /><br>and phosphate control, protein energy wasting) in home dialysis patients, with<br /><br>those in a comparison group of patients treated with conventional in-centre HD;<br /><br>- To analyse the incidence and causes of technique failure of home dialysis -<br /><br>both PD and home (nocturnal) HD;<br /><br>- To compare infectious and non-infectious hospitalisation (rate, time to first<br /><br>hospitalisation and length of hospital stay) between patients on home dialysis<br /><br>and patients treated with conventional in-centre HD;<br /><br>- To compare the mortality rate between patients on home dialysis and patients<br /><br>treated with conventional in centre-HD;<br /><br>- To compare total costs in home dialysis compared to conventional in-centre<br /><br>HD, in order to determine cost-effectiveness of home dialysis;<br /><br>- To analyse experiences of caregivers and caregiver burden.</p><br>