MedPath

Inflammatory Biomarkers of Pediatric Pulmonary Hypertension

Conditions
Hypertension, Pulmonary
Interventions
Other: Blood test
Registration Number
NCT03581695
Lead Sponsor
The Hospital for Sick Children
Brief Summary

To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared to those with CHD alone, or with healthy controls.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
60
Inclusion Criteria

-patients of any age with congenital cardiac disease coming for catheterization of the right heart, or both the right and left heart.

Exclusion Criteria
  • active systemic infection
  • current active cancer
  • active cancer treatment
  • prior bone marrow transplant
  • prior solid organ transplant

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Congenital Heart DiseaseBlood testCongenital Heart Disease
Healthy ControlsBlood testHealthy Controls
Pulmonary Hypertension and Congenital Heart DiseaseBlood testPulmonary Hypertension and Congenital Heart Disease
Primary Outcome Measures
NameTimeMethod
Measurement of HGMB11 day

Measurement of HGMB1

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Hospital for Sick Children

🇨🇦

Toronto, Ontario, Canada

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