Inflammatory Biomarkers of Pediatric Pulmonary Hypertension
- Conditions
- Hypertension, Pulmonary
- Interventions
- Other: Blood test
- Registration Number
- NCT03581695
- Lead Sponsor
- The Hospital for Sick Children
- Brief Summary
To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared to those with CHD alone, or with healthy controls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
-patients of any age with congenital cardiac disease coming for catheterization of the right heart, or both the right and left heart.
Exclusion Criteria
- active systemic infection
- current active cancer
- active cancer treatment
- prior bone marrow transplant
- prior solid organ transplant
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Congenital Heart Disease Blood test Congenital Heart Disease Healthy Controls Blood test Healthy Controls Pulmonary Hypertension and Congenital Heart Disease Blood test Pulmonary Hypertension and Congenital Heart Disease
- Primary Outcome Measures
Name Time Method Measurement of HGMB1 1 day Measurement of HGMB1
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada