External Oblique Intercostal Plane Block Versus Thoracic Paravertebral Block for Post Thoracotomy Pain: A Randomized Non-inferiority Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Total morphine consumption
研究概览
简要总结
The aim of this study is to compare the effectiveness of analgesia achieved by external oblique intercostal plane block (EOIPB)and thoracic paravertebral block (TPVB) for postoperative pain management in patients undergoing open thoracotomy.
详细描述
Acute thoracotomy pain is multifactorial in nature. It involves nociceptive and neuropathic mechanisms originating from somatic and visceral afferents. The main sources of pain are intercostal nerves, the vagus nerve and phrenic nerve in the pleura, the superficial cervical plexus, and the brachial plexus in the ipsilateral shoulder.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •Both sexes.
- •American Society of Anesthesiology (ASA) physical status I-III.
- •Scheduled for open thoracotomy
排除标准
- •Patients with neurological or intellectual disability.
- •Infection at the injection site.
- •Opioid addiction.
- •Allergic reaction to local anesthetics.
- •Coagulation abnormalities.
- •Drug abuse.
- •Pregnancy.
- •Severe liver and/or renal failure.
- •Uncontrolled hypertension.
- •Severe cardiovascular problems.
- •Diabetes mellitus.
结局指标
主要结局
Total morphine consumption
时间窗: 24 hours postoperatively
Rescue analgesia of morphine will be given as 2 mg bolus if the numeric rating scale (NRS) \> 3 to be repeated after 30 min if pain persists until the numeric rating scale \< 4. numeric rating scale will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.
次要结局
- Mean arterial pressure(Till the end of surgery)
- Degree of pain(24 hours postoperatively)
- Heart rate(Till the end of surgery)
- Time to the 1st rescue analgesia(24 hours postoperatively)
- Intraoperative fentanyl consumption(Intraoperative)
- Complications(24 hour postoperatively)
研究者
Mohammed Said ElSharkawy
Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University