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Clinical Trials/ACTRN12614001175662
ACTRN12614001175662
Completed
Phase 3

In patients with traumatic brain injury, does insertion of antibiotic-impregnated external ventricular drains compared with standard drains reduce the incidence of catheter-associated central nervous system infections

The Alfred, Intensive Care Research0 sites280 target enrollmentNovember 7, 2014
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ConditionsTraumatic brain injuryVentriculitisInjuries and Accidents - Other injuries and accidentsInfection - Other infectious diseases

Overview

Phase
Phase 3
Intervention
Not specified
Conditions
Traumatic brain injury
Sponsor
The Alfred, Intensive Care Research
Enrollment
280
Status
Completed
Last Updated
4 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
November 7, 2014
End Date
April 6, 2020
Last Updated
4 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
The Alfred, Intensive Care Research

Eligibility Criteria

Inclusion Criteria

  • •1\. Aged at least 16 years old
  • •2\. Traumatic brain injury requiring external ventricular drain insertion

Exclusion Criteria

  • •1\. Known or suspected CSF infection at time of EVD insertion
  • •2\. Any other indication for ongoing antibiotics at the time of EVD insertion
  • •3\. Prior EVD insertion (last 30 days)
  • •4\. Sepsis, ventriculitis, meningitis, skin infection at implantation site.
  • •5\. Allergy to Rifampicin and Clindamycin
  • •6\. Multiple EVDs required con\-currently

Outcomes

Primary Outcomes

Not specified

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