DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

Phase 2

Recruiting

• Conditions: Medulloblastoma
• Interventions: Drug: Difluoromethylornithine

• Registration Number: NCT04696029
• Lead Sponsor: Giselle Sholler

Brief Summary

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma.

Detailed Description

In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 2500 mg/m2 BID on each day of study.

Subjects will be evaluated in 3 Cohorts:

Cohort 1: Molecular High Risk Medulloblastoma Cohort 2: Molecular Very High Risk Medulloblastoma Cohort 3: Relapsed/Refractory Medulloblastoma

A total of 118 subjects across all cohorts will be enrolled to ensure that there will be 107 evaluable subjects (32-39 per cohort)

Study Timeline

• Study First Submitted: 2021-01-04
• Study First Submitted QC: 2021-01-04
• Study First Posted: 2021-01-06
• Study Start: 2021-03-29
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-19
• Last Update Posted: 2025-05-21
• Primary Completion: 2028-03
• Study Completion: 2029-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

1. Age: 0-21 years of age at diagnosis

2. Pathology All patients must either have a pathologically confirmed diagnosis of medulloblastoma with molecular grouping identified by either Nanostring or methylation profiling.

   Cohort 1- Molecular High Risk:

   • Metastatic non-MYC amplified Group 3
   • Metastatic Group 4
   • Metastatic non-WNT/non-SHH (Must be non-MYC amplified)

   Cohort 2- Molecular Very High Risk

   • Metastatic OR MYCN amplified OR TP53 mutant non-infant (>3 yrs) SHH
   • MYC amplified Group 3
   • Non-WNT, non-SHH infant (< 3 yrs)

   Cohort 3: Relapsed/Refractory Medulloblastoma

3. Pre-enrollment tumor survey:

   Prior to enrollment on this study, a determination of mandatory disease staging must be performed:

   • Tumor imaging studies including: Brain and spine MRI
   • Lumbar Puncture only if previously positive
   • Bone Marrow aspiration/biopsy only if previously positive
   • This disease assessment is required for eligibility and preferably should be done within 2 weeks prior to first dose of study drug, but must be done within a maximum of 4 weeks before first dose of study drug.

4. Disease Status: Subjects must have no evidence of disease, or stable* residual nonbulky** disease.

   *Stable residual disease defined as non-progression over 2 separate imaging studies at least 6 weeks apart

   **Non-bulky disease defined as maximal cross-sectional area < 3cm^2 at enrollment. Patients with leptomeningeal disease are allowed to participate on study.

5. Timing from prior therapy:

   Enrollment (first dose of DFMO) no later than 60 days after last dose of conventional chemotherapy. Patients who have undergone high dose chemotherapy (HDCT) with autologous stem cell transplantation (SCT) are eligible if more than 45 days have elapsed since date of last SCT.

6. Patients must have a Lansky or Karnofsky Performance Scale score of ≥ 50% (see Appendix II) and patients must have a life expectancy of ≥ 2 months.

7. All clinical and laboratory studies for organ functions to determine eligibility must be performed within 7 days prior to first dose of study drug unless otherwise indicated below.

8. Patients must have adequate organ functions at the time of registration:

   • Hematological: Hematological recovery as defined by ANC ≥750/μL, platelets ≥30 (non-transfused x 7 days)
   • Liver: Adequate liver function as defined by AST and ALT <10x upper limit of normal
   • Renal: Adequate renal function defined as (perform one of the following): Creatinine clearance or radioisotope GFR ≥ 70 mL/min/1.73 m2 or a serum creatinine based on age/gender

9. Females of childbearing potential must have a negative pregnancy test. Patients of childbearing potential must agree to use an effective birth control method. Female patients who are lactating must agree to stop breast-feeding.

10. Written informed consent in accordance with institutional and FDA guidelines must be obtained from all subjects (or patients' legal representative).

Exclusion Criteria

1. BSA of <0.25 m2
2. Metastatic disease outside of CNS
3. Relapsed/refractory patients who are radiation-naïve and age 5 years or older at time of enrollment
4. Investigational Drugs: Subjects who are currently receiving another investigational drug are excluded from participation.
5. Anti-cancer Agents: Subjects who are currently receiving other anticancer agents are not eligible. Subjects must have fully recovered from the hematological and bone marrow suppression effects of prior chemotherapy.
6. Infection: Subjects who have an uncontrolled infection are not eligible until the infection is judged to be well controlled in the opinion of the investigator.
7. Subjects who, in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study, or in whom compliance is likely to be suboptimal, should be excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Difluoromethylornithine (DFMO)	Difluoromethylornithine	study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 2500 mg/m2 BID on each day of study.

Primary Outcome Measures

Name	Time	Method
Number of participants with event free survival (EFS) during study	2 years plus 5 years follow up	o To evaluate the efficacy of difluoromethylornithine (DFMO) as a single agent in preventing relapse in patients with molecular high risk and very high risk medulloblastoma, and relapsed/refractory medulloblastoma based upon the 2-year progression-free survival rate (PFS) compared to relevant historical controls.

Secondary Outcome Measures

Name	Time	Method
Determine the Overall Response Rate (ORR) of Participants using Modified RANO Criteria	2 years	To evaluate the efficacy of difluoromethylornithine (DFMO) as a single agent in patients with molecular high risk and very high risk medulloblastoma, and relapsed/refractory medulloblastoma based upon Response Rate for patients with non-bulky residual disease present.
Determine amount of DFMO in the CSF at 3 hours post dose	2 years	o To measure CSF penetration after DFMO administration in pediatric subjects with medulloblastoma
Length of time that participants experience Overall Survival (OS)	7 years	o To evaluate the efficacy of difluoromethylornithine (DFMO) as a single agent in patients with molecular high risk and very high risk medulloblastoma, and relapsed/refractory medulloblastoma based upon overall survival
Number of Participants with Adverse Events as a Measure of Safety and Tolerability	2 years plus 30 days	To develop a complete safety and tolerability profile of difluoromethylornithine (DFMO) in pediatric and young adult subjects with medulloblastoma.

Trial Locations

Locations (15)

Arkansas Children's Hospital; 🇺🇸 Little Rock, Arkansas, United States

UCSF Benioff Children's Hospital Oakland-; 🇺🇸 Oakland, California, United States

Rady Children's Hospital; 🇺🇸 San Diego, California, United States

Connecticut Children's Hospital; 🇺🇸 Hartford, Connecticut, United States

Arnold Palmer Hospital for Children; 🇺🇸 Orlando, Florida, United States

St. Joseph's Children's Hospital; 🇺🇸 Tampa, Florida, United States

Kentucky Children's Hospital; 🇺🇸 Lexington, Kentucky, United States

University of Louisville/Norton's Children's; 🇺🇸 Louisville, Kentucky, United States

Children's Mercy Hospitals and Clinics; 🇺🇸 Kansas City, Missouri, United States

Cardinal Glennon Children's Medical Center; 🇺🇸 Saint Louis, Missouri, United States

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