Tumor-specific T Cells in Lung Cancer
Not Applicable
Active, not recruiting
- Conditions
- Non-small Cell Lung Cancer
- Registration Number
- NCT02515760
- Lead Sponsor
- University Hospital Heidelberg
- Brief Summary
Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear. The aim of this study is to characterize localization and frequencies of spontaneously induced memory T cells specific for a panel of tumor-associated antigens in peripheral blood and bone marrow of non-small cell lung cancer patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- Patients with histology proven non-small cell lung cancer or a lesion suspicious of non-small cell lung cancer (lung cancer group)
- Healthy donors (control group)
- written informed consent
Exclusion Criteria
- Autoimmune disease
- Patients receiving immunomodulatory drugs, e.g. tacrolimus
- Prior malignancy
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Frequencies of tumor-specific T cells 2 weeks postoperative % of all T cells
- Secondary Outcome Measures
Name Time Method Long-term survival 5 years postoperative OS
Tumor-specific T cells location determined by Enzyme Linked Immuno Spot Assay (ELISPOT) analysis of peripheral blood and bone marrow samples from the same patient 2 weeks postoperative location: peripheral versus bone marrow
Trial Locations
- Locations (1)
Division of Thoracic Surgery, Technical University of Munich, Munich, Germany
🇩🇪Munich, Germany
Division of Thoracic Surgery, Technical University of Munich, Munich, Germany🇩🇪Munich, Germany