NCT02515760进行中（未招募）不适用
Tumor-specific Effector T Cells in Non-small Cell Lung Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Frequencies of tumor-specific T cells
研究概览
简要总结
Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear. The aim of this study is to characterize localization and frequencies of spontaneously induced memory T cells specific for a panel of tumor-associated antigens in peripheral blood and bone marrow of non-small cell lung cancer patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with histology proven non-small cell lung cancer or a lesion suspicious of non-small cell lung cancer (lung cancer group)
- •Healthy donors (control group)
- •written informed consent
排除标准
- •Autoimmune disease
- •Patients receiving immunomodulatory drugs, e.g. tacrolimus
- •Prior malignancy
- •Pregnancy
结局指标
主要结局
Frequencies of tumor-specific T cells
时间窗: 2 weeks postoperative
% of all T cells
次要结局
- Tumor-specific T cells location determined by Enzyme Linked Immuno Spot Assay (ELISPOT) analysis of peripheral blood and bone marrow samples from the same patient(2 weeks postoperative)
- Long-term survival(5 years postoperative)
研究者
Dr. med. Seyer Safi
PD Dr. med. Seyer Safi
University Hospital Heidelberg
研究点 (2)
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