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Alliance for Clinical Trials in Oncology

🇺🇸United States

Country: 🇺🇸United States

Ownership: Private

Established: 2011-01-01

Employees: 251

Market Cap: -

Website: https://www.allianceforclinicaltrialsinoncology.org

Clinical Trials

Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

Phase 3

Recruiting

Conditions: Recurrent Non-Muscle Invasive Bladder Carcinoma
Stage 0a Bladder Cancer AJCC v8
Stage I Bladder Cancer AJCC v8

Interventions: Biological: BCG Solution
Procedure: Biopsy of Bladder
Procedure: Cystoscopy
Procedure: Computed Tomography
Procedure: Magnetic Resonance Imaging
Procedure: Biospecimen Collection
Procedure: Transurethral Resection of Bladder Tumor
Drug: Gemcitabine

First Posted Date: 2025-05-31

Last Posted Date: 2025-07-01

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 330

Registration Number: NCT07000084

Locations: 🇺🇸
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States
🇺🇸
Memorial Sloan Kettering Monmouth, Middletown, New Jersey, United States
🇺🇸
Memorial Sloan Kettering Bergen, Montvale, New Jersey, United States

and more 4 locations

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Phase 3

Recruiting

Conditions: Head and Neck Squamous Cell Carcinoma
Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
Stage II Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Interventions: Drug: Gabapentin
Drug: Placebo
Drug: Chemotheraphy
Radiation: Radiation Therapy
Drug: Analgesic Agent
Procedure: Biospecimen Collection
Other: Survey Administration

First Posted Date: 2025-05-28

Last Posted Date: 2025-06-27

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 228

Registration Number: NCT06992427

Locations: 🇺🇸
Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho, United States
🇺🇸
Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho, United States
🇺🇸
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint, Idaho, United States

and more 3 locations

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

Phase 3

Not yet recruiting

Conditions: Castration-Sensitive Prostate Carcinoma
Metastatic Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions: Drug: Androgen Therapy
Drug: Apalutamide
Procedure: Computed Tomography
Drug: Docetaxel
Procedure: Magnetic Resonance Imaging
Procedure: Bone Scan
Procedure: PSMA PET Scan
Procedure: Biospecimen Collection
Other: Questionnaire Administration

First Posted Date: 2025-04-17

Last Posted Date: 2025-04-17

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 1260

Registration Number: NCT06931340

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Phase 3

Not yet recruiting

Conditions: Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Early Stage Breast Carcinoma

Interventions: Biological: Trastuzumab (Herceptin)
Biological: Pertuzumab
Procedure: Echocardiography
Procedure: Multigated Acquisition Scan
Procedure: Mammography
Procedure: Ultrasound
Procedure: Magnetic Resonance Imaging
Procedure: Biospecimen Collection
Other: Questionnaire Administration

First Posted Date: 2025-03-14

Last Posted Date: 2025-03-14

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 1524

Registration Number: NCT06876714

Testing Low Dose Tamoxifen for Invasive Breast Cancer, the (LoTam) Trial

Phase 3

Recruiting

Conditions: Anatomic Stage 0 Breast Cancer AJCC v8
Anatomic Stage 1 Breast Cancer AJCC v8
Anatomic Stage IIA Breast Cancer AJCC v8
Estrogen Receptor-Positive Breast Carcinoma
HER2-Negative Breast Carcinoma

Interventions: Drug: Tamoxifen
Drug: Anastrozole
Procedure: Mammogram
Drug: Letrozole
Drug: Exemestane
Procedure: Magnetic Resonance Imaging
Biological: Dual X-ray Absorptiometry
Procedure: Biospecimen Collection
Other: Questionnaire Administration

First Posted Date: 2024-11-04

Last Posted Date: 2025-06-26

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 1156

Registration Number: NCT06671912

Locations: 🇺🇸
Katmai Oncology Group, Anchorage, Alaska, United States
🇺🇸
Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States
🇺🇸
Mercy Hospital Fort Smith, Fort Smith, Arkansas, United States

and more 418 locations

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

Phase 3

Recruiting

Conditions: Clear Cell Renal Cell Carcinoma
Renal Cell Carcinoma (RCC)
Stage II Renal Pelvis Cancer AJCC v8
Stage III Renal Pelvis Cancer AJCC v8

Interventions: Biological: Pembrolizumab
Procedure: Biospecimen Collection
Drug: Tivozanib
Procedure: MRI
Procedure: Computed Tomography
Procedure: Biopsy
Other: Questionnaire Administration

First Posted Date: 2024-10-28

Last Posted Date: 2025-06-26

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 1040

Registration Number: NCT06661720

Locations: 🇺🇸
Cancer Center at Saint Joseph's, Phoenix, Arizona, United States
🇺🇸
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas, United States
🇺🇸
City of Hope Comprehensive Cancer Center, Duarte, California, United States

and more 204 locations

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

Phase 2

Recruiting

Conditions: Castration-Resistant Prostate Carcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions: Other: Genetic testing
Drug: Valemetostat Tosylate
Procedure: Magnetic Resonance Imaging
Procedure: Computed Tomography
Procedure: Bone scan
Procedure: FDG-Positron Emission Tomography
Procedure: PSMA PET Scan
Procedure: Biospecimen Collection
Drug: Carboplatin
Drug: Cabazitaxel
Drug: Abiraterone Acetate
Drug: Enzalutamide
Drug: Lutetium Lu 177 Vipivotide Tetraxetan

First Posted Date: 2024-10-09

Last Posted Date: 2025-06-26

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 474

Registration Number: NCT06632977

Locations: 🇺🇸
Banner University Medical Center - Tucson, Tucson, Arizona, United States
🇺🇸
University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States
🇺🇸
UC San Diego Health System - Encinitas, Encinitas, California, United States

and more 40 locations

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Phase 3

Recruiting

Conditions: Resectable Lung Non-Small Cell Carcinoma
Stage II Lung Cancer AJCC v8
Stage IIIA Lung Cancer AJCC v8
Stage IIIB Lung Cancer AJCC v8

Interventions: Procedure: Surgical Procedure
Drug: Cisplatin
Drug: Carboplatin
Drug: Pemetrexed
Drug: Gemcitabine
Drug: Docetaxel
Drug: Vinorelbine
Drug: Nivolumab
Drug: Pembrolizumab
Drug: Atezolizumab
Procedure: Computed Tomography
Procedure: Magnetic Resonance Imaging
Procedure: Positron Emission Tomography

First Posted Date: 2024-10-09

Last Posted Date: 2025-06-27

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 1100

Registration Number: NCT06632327

Locations: 🇺🇸
Cancer Center at Saint Joseph's, Phoenix, Arizona, United States
🇺🇸
Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States
🇺🇸
Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande, California, United States

and more 324 locations

Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myeloma

Phase 1

Suspended

Conditions: Recurrent Multiple Myeloma
Refractory Multiple Myeloma

Interventions: Drug: Iberdomide
Biological: Belantamab Mafodotin
Drug: Dexamethasone
Procedure: Echocardiography
Procedure: Computed Tomography
Procedure: Magnetic Resonance Imaging
Procedure: Positron Emission Tomography
Procedure: Bone Marrow Biopsy
Procedure: Bone Marrow Aspiration
Procedure: Biospecimen Collection

First Posted Date: 2024-01-30

Last Posted Date: 2025-06-27

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 88

Registration Number: NCT06232044

Locations: 🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
🇺🇸
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States

and more 35 locations

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

Phase 2

Recruiting

Conditions: Pancreatic Acinar Cell Carcinoma
Pancreatic Adenocarcinoma
Pancreatic Adenosquamous Carcinoma
Pancreatic Carcinoma
Pancreatic Ductal Adenocarcinoma
Stage IV Pancreatic Cancer AJCC v8
Pancreatic Squamous Cell Carcinoma

Interventions: Drug: Nab paclitaxel
Drug: Gemcitabine
Drug: Cisplatin
Procedure: Magnetic Resonance Imaging
Procedure: Computed Tomography
Procedure: Biospecimen Collection

First Posted Date: 2023-11-03

Last Posted Date: 2025-04-02

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 100

Registration Number: NCT06115499

Locations: 🇺🇸
Mercy Medical Center, Durango, Colorado, United States
🇺🇸
Southwest Oncology PC, Durango, Colorado, United States
🇺🇸
Saint Anthony Hospital, Lakewood, Colorado, United States

and more 305 locations

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