The Comparison of Thick Split-thickness Skin Graft Versus Thin Split-thickness Skin Graft in the Reconstruction of the Donor Site
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- healing time of the donor sites
Overview
Brief Summary
In clinical settings, split-thickness skin graft (STSG) remain the gold standard for covering large skin defects. However, STSGs usually bring complications to the donor sites. The study objective was to compare the efficacy of thick split-thickness skin graft versus thin split-thickness skin graft in the reconstruction of the donor site.
Detailed Description
All patients were randomly divided into two groups. For the patients in the thick STSG group, the surgeons harvested thick STSGs which were larger than recipient sites. The extra skin was punctured and stretched to cover the donor site (the novel technique). For the patients in the thin STSG group, the surgeons harvested thick STSGs of the size of recipient sites. Their donor sites were covered with thin STSGs which were harvested from other parts of the patients. The 36-item short form health survey (SF-36) scores, pain scores, pruritus scores, scar scores and rates of complications were compared between the two groups.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients had skin defects at functional sites or joint sites.
- •Patients aged 20-80 years.
- •The lateral thighs were chosen as the donor sites.
Exclusion Criteria
- •Patients who were unable to complete the follow-up.
- •Pregnant or nursing mothers were not included.
- •Patients had an alternative source of pain other than surgical sites.
- •Patients with organ dysfunctions (heart failure, respiratory failure, liver dysfunction, renal impairment or intestinal failure), or cancers.
- •Patients with autoimmune diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, Sjogren's syndrome, connective tissues disease or systemic vasculitis) were not included.
- •Patients who had medications (such as corticosteroids, immunosuppressive agents or chemotherapy) within six months were not included.
- •Other reasons.
Outcomes
Primary Outcomes
healing time of the donor sites
Time Frame: 2 months post surgery
The complete healing time of the donor sites was defined as the day when 100% epithelialization was achieved,
Secondary Outcomes
- pains scores (Visual Analogue Scales)(on Day 1 and Day 7 postoperatively)
- pruritus scores(at 3 months and at 6 months post-surgery)
- scars scores ( Vancouver Scar Scales )(at 3 months and 6 months post-surgery)
- life quality (36-item short form health survey scores)(Prior to surgery or at 6 months post-surgery)
Investigators
YinWu
attending doctor of Department of Burn and Plastic Surgery,Nanjing First Hospital
Nanjing First Hospital, Nanjing Medical University