Impact of Cholesterol Level on Long-term Coronary Bypass Graft Patency

Withdrawn

• Conditions: Bypass Graft Stenosis; Coronary Artery Stenosis; Hypercholesterolemia; Dyslipidemias; Bypass Graft Occlusion; Coronary Artery Disease; Coronary Bypass Graft Stenosis; Hyperlipidemia

• Registration Number: NCT05393882
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

This single-centre cross-sectional study aims to ascertain the impact of dyslipidemia on long-term graft patency after coronary artery bypass grafting (CABG).

Detailed Description

All consecutive patients who underwent CABG from 1st January 2007 to 31st December 2008 at the Prince of Wales Hospital were eligible for entry.

Graft patency will be determined by computed tomography coronary angiogram. The severity of stenosis will be classified by the Fitzgibbon classification system.

The levels of individual lipid profile subcomponents, namely LDL-C, high-density lipoprotein cholesterol (HDL-C), total cholesterol and triglycerides (TG) will be obtained. A plot of lipid profile subcomponent measurements against time will be compiled and the area under the curve is calculated to estimate gross exposure after CABG. Average lipid exposure is calculated by dividing the gross exposure by the number of days lapsed between the first and last lipid profile measurements.

The association between average cholesterol target attainment and graft patency will then be determined.

Study Timeline

• Study First Submitted: 2022-05-20
• Study First Submitted QC: 2022-05-24
• Study First Posted: 2022-05-26
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-21
• Last Update Posted: 2024-08-22
• Study Start: 2024-09-01
• Primary Completion: 2026-07-01
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• All consecutive patients on record who underwent coronary artery bypass graft surgery in 2007 and 2008

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Exclusion Criteria

• Death
• Single vessel LIMA-LAD anastomosis only
• Concomitant valve and aortic procedures
• Concomitant repair of post-infarct ventricular septal rupture
• Defaulted follow-up
• Informed consent cannot be obtained
• Intermediate to high risk for contrast nephropathy, defined as estimated glomerular filtration rate less than 45 ml/min/1.73m2 or serum creatinine level <1.5 mg/dL (based on American College of Radiology criteria for diagnostic computed tomography risk)
• Pregnancy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Graft patency	Immediately after CTCA	Graft patency as assessed by computed tomographic coronary angiogram, using Fitzgibbon classification

Secondary Outcome Measures

Name	Time	Method
Actuarial cardiac events	Immediately after CTCA	Events attributable to cardiac causes as adjudicated by the investigators, including congestive heart failure, ischaemic cardiomyopathy, myocardial infarction, ventricular arrhythmias, recurrent angina

Trial Locations

Locations (1)

Prince of Wales Hospital; 🇭🇰 Hong Kong, Hong Kong