Observational Study of the Correlation Between Peripheral Treg Cell Senescence and Serum Total Cholesterol Level
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypercholesterolemia
- Sponsor
- Tianjin Medical University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Treg cell senescence
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Hypercholesterolemia is a risk factor for the occurrence and development of atherosclerosis. Recent animal studies have found that increased serum cholesterol level is associated with peripheral Treg cell senescence, but clinical evidence is still lacking. The purpose of this study is to analyze the correlation between human peripheral Treg cell senescence and serum total cholesterol level using clinical blood samples, thus laying a foundation for the establishment of novel therapeutic strategies for atherosclerosis based on the regulation of Treg cell senescence.
Detailed Description
Hypercholesterolemia is a risk factor for the occurrence and development of atherosclerosis. Recent animal studies have found that increased serum cholesterol level is associated with peripheral Treg cell senescence, but clinical evidence is still lacking. The purpose of this study is to analyze the correlation between human peripheral Treg cell senescence and serum total cholesterol level using clinical blood samples, thus laying a foundation for the establishment of novel therapeutic strategies for atherosclerosis based on the regulation of Treg cell senescence.
Investigators
Xintong Ge
Professor
Tianjin Medical University General Hospital
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 30 and ≤ 60 years old with independent behavior ability.
- •The participants need to fully understand the purpose and content of the study, and voluntarily participate in the study and sign the informed consent.
Exclusion Criteria
- •Pregnant or lactating women.
- •Acute and severe diseases in the last 3 months, including but not limited to, acute myocardial infarction, acute cerebral infarction, cerebral hemorrhage, circulatory failure, respiratory failure (internal diseases), trauma requiring hospitalization, or undergoes surgery under general anesthesia (surgical diseases).
- •History of severe diseases, including but not limited to, tumors, serious hematological diseases, serious cardiopulmonary diseases (interventional therapy for coronary artery disease, atrial fibrillation, chronic obstructive pulmonary disease, etc.), renal failure, liver failure, old stroke with serious sequelae.
- •Have participated in clinical trials in the past 3 months.
- •The investigator considers that not appropriate for inclusion.
Outcomes
Primary Outcomes
Treg cell senescence
Time Frame: After confirming the subject has signed the informed consent, and recorded the past medical history and medication (especially hypolipidemic drugs) in the past 3 months.
Treg cell senescence will be evaluated by the beta-galactosidase (SA-betagal) activity test