The Effect of Supplementation with Curcuminoids for the Improvement of Musculoskeletal Conditions in Sedentary Adults

Phase 3

Completed

• Conditions: Sedentariness and Well-being

• Registration Number: NCT06757452
• Lead Sponsor: Lissette Ariza Corredor

Brief Summary

The aim of this study is to evaluate the effect of a supplementation with curcuminoids, called Cal LX, prior to physical exercise, on the improvement of musculoskeletal conditions in sedentary people, which would lead to more physical exercise regularly.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-05
• Primary Completion: 2023-11-08
• Study Completion: 2023-11-08
• Status Verified: 2024-12
• Study First Submitted: 2024-12-19
• Study First Submitted QC: 2024-12-26
• Study First Posted: 2025-01-03
• Last Update Submitted: 2025-01-07
• Last Update Posted: 2025-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• To be over 25 years old
• To have not exercised systematically during the last 3 months, or do not do physical exercise daily for more than 25 minutes per day for a maximum of 3 days per week
• Sitting for at least 4 hours continuously
• Type 2 diabetes patients.

Exclusion Criteria

• To have a history or diagnoses of cardiopulmonary, osteoarticular, type 1 diabetes or autoimmune disorders
• Pregnancy
• Smokers.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
RMSSD	Twice a week, prior and after the physical activity, during the three monts of intervention	An indicator of parasympathetic activity by evaluating the root mean square of successive differences between normal heartbeats (RMSSD) determined in milliseconds, which is directly associated with short-term heart rate variability.

Secondary Outcome Measures

Name	Time	Method
Creatinine	Every 30 days, begining the first day physical activity, during the three monts of intervention.	Creatinine is a waste product that comes from the digestion of protein in your food and the normal breakdown of muscle tissue. It is removed from the blood through your kidneys.
CK	Every 30 days, begining the first day physical activity, during the three monts of intervention.	Creatine kinase is an enzyme that's responsible for healthy muscle function. When muscles break down, they release CK, elevating the protein levels in your blood.
LDH	Every 30 days, begining the first day physical activity, during the three monts of intervention.	LDH is an enzyme found in many body tissues such as the heart, liver, kidney, skeletal muscle, brain, blood cells, and lungs. When body tissue is damaged, LDH is released into the blood.
Urea	Every 30 days, begining the first day physical activity, during the three monts of intervention.	Urea and creatinine levels are used to evaluate kidney function.
SOD	Every 30 days, begining the first day physical activity, during the three monts of intervention.	Superoxide dismutase (SOD) is an enzyme found in all living cells. An enzyme is a substance that speeds up certain chemical reactions in the body. Superoxide dismutase helps break down potentially harmful oxygen molecules in cells.

Trial Locations

Locations (1)

Universidad de Caldas; 🇨🇴 Manizales, Caldas, Colombia