Gas Exchange and CT Effects of PEEP in ARDS
Not Applicable
Completed
- Conditions
- ARDS
- Interventions
- Diagnostic Test: ALPE
- Registration Number
- NCT04067154
- Lead Sponsor
- Policlinico Hospital
- Brief Summary
The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results
- Detailed Description
In ARDS patients on mechanical ventilation, we will compare model-based estimation of gas exchange parameters (shunt, ventilation/perfusion mismatch) with CT-based estimation of effects of low and high PEEP
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
- ARDS patients requiring mechanical ventilation
Exclusion Criteria
- <18 years old
- Requirement of extracorporal life support
- Hemodynamic instability
- Barotrauma
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description ALPE-TAC ALPE ARDS patients on mechanical ventilation. Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O to evaluate potential for recruitment and measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O
- Primary Outcome Measures
Name Time Method Gas Exchange and lung recruitability at diferent PEEP levels Approximately two hours Gas exchange (At PEEP 5 and 20 cm H2O), CT scan (At PEEP 5, 20 and 45 cm H2O)
- Secondary Outcome Measures
Name Time Method Physiologic Parameter 1 Approximately two hours Hemodynamic assessment at different PEEP levels
Physiologic Parameter 2 Approximately two hours Respiratory mechanics at different PEEP levels
Trial Locations
- Locations (1)
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
🇮🇹Milano, MI, Italy