PEEP Influence on Gas Exchange During Early Weaning

Not Applicable

Withdrawn

• Conditions: Respiratory Failure
• Interventions: Other: PEEP adjusment during the Weaning process

• Registration Number: NCT02281695
• Lead Sponsor: Marienhospital Osnabrück

Brief Summary

The purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.

Detailed Description

First, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. After 5 minutes an PaO2/FiO2 will be calculated and compared with a PaO2/FiO2 during ventilation with FiO2 - 30%.

The patients will be divided in two sections: Section A are the patients with less than 24 hours mechanical ventilation until weaning start. Section B are the patients with more than 24 hours until weaning start.

The patients in every section will be further divided in two groups. Group 1 will be weaned starting with a PEEP equal with P mean during BiPAP, Group 2 will be weaned starting with a PEEP equal with PEEP during BiPAP.

Further, the weaning will be conducted after an known algorithm. The differences in the oxygenation and decarboxylation will be measured after 30 and 120 Minutes for Group A and after 30, 120, 240, 360 Minutes for Group B.

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2014-10-29
• Study First Submitted QC: 2014-10-30
• Study First Posted: 2014-11-02
• Primary Completion: 2018-11
• Study Completion: 2018-12
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-29
• Last Update Posted: 2022-09-01

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• All Patients that are mechanical ventilated on the intensive care unit.

Exclusion Criteria

• Patients under 18 years of age
• Patients that where in an other study in the last 30 days
• Patients that are enrolled in other studies
• Pregnant woman
• Nursing mothers
• Existing severe Lung disease
• Existing COPD Gold IV

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Arm A	PEEP adjusment during the Weaning process	Patients that are mechanically ventilated for less than 24 hours until the weaning process can be started. At the beginning of the weaning process the PEEP will be adjusted at a value equal with the PEEP during BiPAP (Group 1) and Pmean during BiPAP (Group 2) During controlled mechanical ventilation all patients will be for 5 minutes with FiO2 - 100% ventilated. The PaO2/FiO2 after 5 minutes ventilation with 100% oxygen will be compared with the PaO2/FiO2 during ventilation with 30% oxygen.
Arm B	PEEP adjusment during the Weaning process	Patients that are mechanically ventilated for more than 24 hours until the weaning process can be started. At the beginning of the weaning process the PEEP will be adjusted at a value equal with the PEEP during BiPAP (Group 1) and Pmean during BiPAP (Group 2) During controlled mechanical ventilation all patients will be for 5 minutes with FiO2 - 100% ventilated. The PaO2/FiO2 after 5 minutes ventilation with 100% oxygen will be compared with the PaO2/FiO2 during ventilation with 30% oxygen.

Primary Outcome Measures

Name	Time	Method
Changes in the Oxygen Partial Pressure and CO2 Partial Pressure in the arterial blood gas analysis	30, 60, 90, 120, 360 Minutes

Trial Locations

Locations (1)

Marienhospital Osnabrück; 🇩🇪 Osnabrück, Niedersachsen, Germany