Ovarian Ageing in type 1 Diabetes Mellitus: the role of vascular factors

Completed

• Conditions: ageing of the ovaries in women with diabetes; ovarian ageing in type 1 diabetes; 10012653; 10074469

• Registration Number: NL-OMON38166
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-04-10
• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 310

Inclusion Criteria

Patients: females diagnosed with type 1 diabetes mellitus
Controls: healthy age-matched female controls

Exclusion Criteria

Induced menopause: surgical (premenopausal hysterectomy and/or bilateral ovariectomy), chemo- or radiation therapy, ovarian surgery and irregular menstrual cycles.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Part I:<br /><br>1. Age specific AMH level<br /><br>2. Number of antral follicles present in the ovaries<br /><br>3. Vascular status using the ENDOVAS screening.<br /><br><br /><br>Part II:<br /><br>1. Age in years at natural menopause assesed by means of questionnaires </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Part I:<br /><br>1. Metabolic status<br /><br>2. Factors associated with early menopause: common genetic variants and<br /><br>auto-immune factors<br /><br><br /><br>Part II:<br /><br>1. Metabolic status if present in patient records. </p><br>