How does dietary protein, when combined with carbohydrate, influence postprandial glucose levels in individuals with type 1 diabetes mellitus?
- Conditions
- Type 1 diabetes mellitusMetabolic and Endocrine - Diabetes
- Registration Number
- ACTRN12614000471684
- Lead Sponsor
- John Hunter Children's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
Type 1 diabetes for at least 12 months
HbA1c 8.0% or less
BMI < 97th centile
Using intensive insulin therapy (multiple daily injection therapy or insulin pump therapy)
Exclusion Criteria
HbA1c greater than 8.0%
BMI greater than 97th centile
Presence of any complications of diabetes
Presence of any other major medical conditions
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is the mean glucose excursion from the consumption of the test meal, measured at 30 minute intervals, up to 300 minutes. Glucose will be meaured using continuous glucose monitoring (CGM) which measures interstitial glucose levels continually, sending updated readings to a small reciever every 5 minutes. At the end of the study period the reciever will be uploaded to a computer data base, allowing for analysis of the glucose measurements after each test meal.[The primary timepoint is 300 minutes, measured at 30 minute intervals from the time of consumption of the test meal. ]
- Secondary Outcome Measures
Name Time Method Secondary outcome will be the velocity of the glucose rise following consumption of the test meal.<br>The glucose rise will be measured using CGM overnight following consumption of the test meal. At the end of the study the CGM receiver will be uploaded to a computer data base where the data can be analysed and a graph produced to display the mean velocity of the glucose rise.[measured at 30 minute intervals to 300 minutes]