Relationship between type I diabetes mellitus and salivary oxidative stress biomarkers : A study in a group of Thais

Not Applicable

Completed

• Conditions: saliva; Type 1 diabetes mellitus patients have higher of MDA, PC, TOS levels than healthy subjectsType 1 diabetes mellitus patients have lower of TAOC levels than healthy subjects; oxidative stress; malondialdehyde; MDA; protein carbonyl; PC; total antioxidant capacity

• Registration Number: TCTR20190506003
• Lead Sponsor: Faculty of Dentistry, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-12-29
• Study Start: 2019-05-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Type 1 diabetes mellitus patients which HbA1C > 7% have been treated at Siriraj hospital
Control group is healthy patients who have age matched with type 1 diabetes mellitus patients

Exclusion Criteria

1. Patient who have been periodontitis as a manifestation of systemic diseases such as Leukocyte adhesion deficiency, Ehler danlos syndrome, neutropenia, Down sysdrome, Papillon Lefvere sysdrome, Chediak Higashi sysdrome, Histiocytosis sysdrome, Glycogen storage disease, Infantile genetic agranulocytosis, Cohen syndrome, Hyphosphatasia, and leukemia
2. Immunodeficiency patients
3. Patients who cannot cooperate due to a lack of psychological or emotional maturity and/or mental physical or medical disability
4. Patients who take medication that effecting periodontium, bleeding disorder, and infection
5. Patients who recieved bisphosphonate
6. Patients who recieved orthodontics treatment
7. Smkoing
8. Pregnant
9. Patients who have deciduous teeth
10. Patients who recieved periodontal treatment within 6 months

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
salivary malondialdehyde levels 0 second The absorbance at 532nm using a spectrophotometer,salivary protein carbonyl levels 0 second The absorbance at 375nm using a spectrophotometer,salivary total antioxidant capacity levels 0 second The absorbance at 405nm using a spectrophotometer,salivary total oxidant status levels 0 second The absorbance at 530nm using a spectrophotometer

Secondary Outcome Measures

Name	Time	Method
probing depth 0 second millimetre/PCPUNC15, Hu-Friedy,clinical attachment level 0 second millimetre/PCPUNC15, Hu-Friedy,bleeding on probing 10 second observe bleeding after gentle probing/PCPUNC15, Hu-Friedy,plaque index 0 second observe plaque accumulation