In people with type 1 diabetes, can an artificial pancreas algorithm improve postprandial glycaemic control following an unannounced meal compared with traditional carbohydrate counting?
Not Applicable
- Conditions
- Type 1 diabetesMetabolic and Endocrine - Diabetes
- Registration Number
- ACTRN12615000666527
- Lead Sponsor
- John Hunter Children's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
1.Type 1 diabetes mellitus for over 1 year
2.HbA1c less than or equal to 69 mmol/mol (8.5%)
3.Age 12y to 45yo
4.Body mass index less than or equal to 97th percentile
5.No other medical conditions
6.No diabetes complications
Exclusion Criteria
1.Unwilling/unable to comply with study protocol
2.HbA1c > 69 mmol/mol (> 8.5%)
3.Any medical condition other than type 1 diabetes
4.Diabetes complications including gastroparesis
5.Medications that would alter glycaemic response
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean blood glucose level[30 minute intervals for 4 hours commencing at the time of the meal]
- Secondary Outcome Measures
Name Time Method Incidence of hypoglycaemia (<4 mmol/L) measured through capillary blood sampling and a glucometer. [30 minutes intervals for 4 hours commencing at the time of the meal];Peak blood glucose level[30 minute intervals over 4 hours commencing at the time of the meal];Time to peak blood glucose level[30 minute intervals over 4 hours commencing at the time of the meal];Incremental area under the curve above the target blood glucose level (10 mmol/L)[30 minute intervals over 4 hours commencing at the time of the meal];Incremental area under the curve below the target blood glucose level (4 mmol/L)[30 minute intervals over 4 hours commencing at the time of the meal];Blood glucose level at conclusion of trial[4 hours postprandially (i.e. 9pm)]