MMRF Molecular Profiling Protocol
- Conditions
- Plasma MalignancyMultiple Myeloma
- Registration Number
- NCT02884102
- Lead Sponsor
- Multiple Myeloma Research Foundation
- Brief Summary
This protocol is now being used as screening for the MyDRUG study
- Detailed Description
Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1000
- Patients must have a diagnosis of multiple myeloma or related malignancy
- Patients are undergoing standard of care bone marrow aspirates
- Patients (male or female) from any race or ethnicity must be at least 18 years of age at the time of registration.
- Procedure-specific signed informed consent form prior to initiation of any study-related procedures.
- It is the enrolling study physician's discretion to decide if a patient is not fit enough to undergo a bone marrow aspirate.
- Patients who are incarcerated are not eligible to participate.
- Women who are pregnant
- Patients who have had another malignancy within the last five (5) years (except for basal or squamous cell carcinoma, or in situ cancer of the cervix) where there is a possibility to contaminate the bone marrow aspirate.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method actionable mutations report 10-14 days
- Secondary Outcome Measures
Name Time Method Disease Recurrence Time to Progression Survival Rates Overall survival
Trial Locations
- Locations (20)
Mayo Clinic - Scottsdale
🇺🇸Scottsdale, Arizona, United States
City of Hope
🇺🇸Duarte, California, United States
UCSF Medical Center
🇺🇸San Francisco, California, United States
Mayo Clinic - Jacksonville
🇺🇸Jacksonville, Florida, United States
Emory University
🇺🇸Atlanta, Georgia, United States
University of Chicago
🇺🇸Chicago, Illinois, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
Barbara Ann Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Scroll for more (10 remaining)Mayo Clinic - Scottsdale🇺🇸Scottsdale, Arizona, United States