Assessment of diaphragmatic parameters using ultrasound for predicting weaning outcome in patients on mechanical ventilation in intensive care unit setting

Not yet recruiting

• Conditions: Measurement and Monitoring, (2) ICD-10 Condition: B||Imaging,

• Registration Number: CTRI/2020/02/023662
• Lead Sponsor: Vardhman Mahavir Medical College and Safdarjung Hospital

Brief Summary

The proposed cohort study will be conducted in the Department of Anaesthesia and Intensive care, Vardhman Mahavir Medical College and Safdarjung Hospital, In 50 patients of age >18years over a period of 18 months. The aim of this study is to ultrasonographically assess diaphragmatic parameters for predicting weaning outcome in patients on mechanical ventilation in the intensive care unit setting. It will assess the diagnostic accuracy of diaphragmatic excursion and diaphragmatic thickness fraction by ultrasonography to predict weaning outcome in patients on mechanical ventilation.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-02-03
• Last Update Posted: 2020-02-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Readiness for weaning from mechanical ventilation as assessed by Recovery from the cause of respiratory failure, Stable haemodynamic status with no requirement for vasopressors, Fully conscious, Glasgow Coma Scale Less than or equal to 14, Fraction of inspired oxygen (Fio2) less than0.5,positive end expiration pressure (PEEP) Less than or equal to 5cm H2O, respiratory rate less than 30, partial pressure of oxygen (PaO2)/FiO2 more than 200.

Exclusion Criteria

• Pneumothorax, pleural effusion, collapse, fibrosis 2.
• History of neuromuscular disease, diaphragmatic palsy, thoracic surgery, any mass or mechanical factor in chest or abdomen 3.Tracheostomy tube in situ 4.
• Pregnancy, ascites, morbid obesity 5.
• Surgical dressings over the right lower rib cage.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnostic accuracy of diaphragmatic excursion and diaphragmatic thickness fraction by ultrasonography predicting weaning outcome in patients on mechanical ventilation.	Patient hemodynamically stable, ventilating on T-piece for 1 hour

Secondary Outcome Measures

Name	Time	Method
correlation between diaphragmatic dysfunction with reintubation	within 48 hours of extubation
Better predictor of diaphragmatic excursion or diaphragmatic thickness fraction	After extubation
compare diaphragmatic rapid shallow breathing index (RSBI) with clinical RSBI	before extubation

Trial Locations

Locations (1)

Vardhman Mahavir medical college and Safdarjung hospital; 🇮🇳 West, DELHI, India

Vardhman Mahavir medical college and Safdarjung hospital

🇮🇳West, DELHI, India

Dr Sakshi Gupta

Principal investigator

9711537301

Sakshigupta2705@gmail.com