Anatomical and Structural Connectivity in Schizophrenias
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 162
- 试验地点
- 1
- 主要终点
- Changes in structural and functional connectivity according to the phenotype. Correlation between these changes
研究概览
简要总结
The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways.
The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects.
The coherence between structural and functional anomalies will be especially studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Changes in structural and functional connectivity according to the phenotype. Correlation between these changes
时间窗: Subjects will be assessed only once.
Statistical parametric mapping (SPM) will be applied on quantitative maps : rCBF (ml/100g/min), susceptibility (part per billion), R1, R2, R2\* (all expressed in ms-1), fractional anisotropy (fraction), averaged diffusivity (μm²/sec), macromolecular proton fraction (percentage), cortical thickness (mm), VBM (probability of grey and white matter) and contrast maps (BOLD signal correlation with the anterior cingulate ROI).
次要结局
- Changes in rCBF and cognition according to the phenotype. Correlation between the different changes and the symptomatic scales.(Subjects will be assessed only once.)