Study by Electroencephalography of the Link Between the Lack of Self-compassion and the Disorder of Empathy in Schizophrenia

Not Applicable

Completed

• Conditions: Schizophrenia; Schizoaffective Disorder
• Interventions: Device: Electroencephalogram

• Registration Number: NCT05464563
• Lead Sponsor: Centre Hospitalier Henri Laborit

Brief Summary

This research project focuses on a fundamental element of the psychopathology of schizophrenia, that is to say, the disorders of self-awareness and on the functional alterations associated with it, that is to say, self-compassion deficit and empathy disorder.

It will be a question of better understanding the neuro-functional mechanisms which underlie the lack of self-compassion and the disorder of empathy in schizophrenia, the relationship that these disorders maintain between them but also the relationship that they maintain with the general psychopathology of schizophrenia and, in particular, with the abnormalities of the self. In other words, the overall framework of this project is that of the link between the psychopathology of schizophrenia and the functional impairment associated with it. Its specific field of application is that of the link between self-awareness disorders, self-compassion deficit and empathy disorder. For this, this project proposes a methodological approach combining the recording of intrinsic and extrinsic brain activity using high-density electroencephalography (EEG).

Detailed Description

This study includes patients (n=30) and healthy volunteers (n=30).

At inclusion visit, participants have:

* a psychiatric evaluation;

* self evaluation of: empathy, self-compassion, émotionnel processing, anxiety, insight, perceptual aberration and quality of life;

* training to practise of self-compassion and empathy (for patients only).

During the phase of experimentation, the participants have electroencephalogram exams during a rest phase, a self-compasion task and an empathy task.

Study Timeline

• Study Start: 2022-03-22
• Study First Submitted: 2022-04-21
• Study First Submitted QC: 2022-07-18
• Study First Posted: 2022-07-19
• Primary Completion: 2024-01-01
• Study Completion: 2024-01-01
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patient group	Electroencephalogram	Patients have electroencephalogram records during : * a phase of rest; * a task of self-compassion * a task of empathy.
Control group	Electroencephalogram	Healthy volunteers have electroencephalogram records during : * a phase of rest; * a task of self-compassion * a task of empathy.

Primary Outcome Measures

Name	Time	Method
Correlation between the temporal parameters of the EEG microstates C, D, E and F (duration, contribution, occurrence) and the inter-subject correlation index during the practice of self-compassion and the practice of empathy.	through study completion, an average of 36 months.	Correlation between the temporal parameters of the EEG microstates C, D, E and F (duration, contribution, occurrence) and the inter-subject correlation index during the practice of self-compassion and the practice of empathy.

Trial Locations

Locations (1)

Centre Hospitalier Henri Laborit; 🇫🇷 Poitiers, France