Pilot Study: the Links Between Basic Auditory Processes and High Functioning Cognitive Processes in Schizophrenia (Reality Monitoring and Emotional Perception)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Performance on a Reality monitoring task and on an externalization task
研究概览
简要总结
Schizophrenia is a mental illness with a variety of clinical symptoms that can be regrouped into 2 categories: positive and negative symptoms.
This mental illness is also characterised by cognitive alterations in various fields, including social cognition difficulties and self / non-self-discrimination difficulties.
Self and non-self-discrimination abilities have been regrouped under a function called source memory. This source memory enables a person to identify the source of an information previously encoded. In our everyday life, these processes are necessary to distinguish events generated by an external source from imagined events. It is called reality monitoring.
A number of studies have evidenced reality-monitoring alterations in patients suffering from schizophrenia. More specifically, patients would present with an externalisation bias, they would assign more imagined events to an external source. The knowledge of these deficits encourages the study of the processes involved in order to better understand the alterations, particularly including auditory processes. A recent study has shown that discrimination errors concerning certain sound characteristics (e.g. frequency) were associated to reality monitoring errors. However, the links between reality-monitoring and basic auditory processes have rarely been explored.
The dysfunction of the auditory "where" path, especially the possibility to discriminate between the intra and extra cephalic localisation of sounds, could lead to difficulties to discern between what is produced by one self and what is produced by another or the local environment.
详细描述
The main objective of this study is to study the links between source memory deficits and externalization abilities in schizophrenic patients and healthy subjects.
Also, this study will:
- evaluate the impact of emotional content on the ability to externalize an auditory perception
- evaluate the abilities to separate sources concerning vocal stimuli
- evaluate the basic auditory processes In order to meet the objectives, the correlation between the percentage of good attributions in the reality monitoring task and the percentage of correct perceptions in/out (sound perceived as coming from inside or outside the head) will be analyzed in the externalization task in patients suffering from schizophrenia.
Will also be analyzed:
- the number of correct perceptions In/Out in the externalization task
- the number of correct perceptions In/Out for the emotional stimuli
- the detection level of difference in pitch between 2 vocal sources pour the height discrimination task
- the number of correctly identified words in the speech-in-speech task
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects aged between 18 and 65 years old - written given consent
- •For patients with schizophrenia:
- •- that meet the DSM-5.0 schizophrenia criteria
- •For healthy control subjects:
- •absence of psychiatric disroders (past and actual) diagnosed according to the DSM-5.0
- •absence of prodromal psychosis as measured by a score under 6 at the Prodromal Questionnaire PQ-16 (Ising et al., 2012)
- •absence of auditory disorders (actual and past) (including tinnitus)
- •absence of medical treatment (to the exception of contraceptive pills
排除标准
- •history of neurological disorders or brain injury with loss of consciousness
- •subjects presenting with highly developed musical abilities (frequently practicing a musical instrument)
- •subjects presenting with an intellectual deficiency as measured by the Raven progressive matrices
- •subjects under guardianship
研究组 & 干预措施
Patient group with schizophrenia
The schizophrenic subjects will undertake a 3 hour session of cognitive experiments. Tasks will include a battery of psychoacoustic tests, a source monitoring task, an externalization task, a pitch discrimination task and a speech-in-speech task.
干预措施: cognitive experiments' session (Behavioral)
Healthy control subjects
Healthy control subjects will undertake a 3 hour session of cognitive experiments. Tasks will include a battery of psychoacoustic tests, a source monitoring task, an externalization task, a pitch discrimination task and a speech-in-speech task.
干预措施: cognitive experiments' session (Behavioral)
结局指标
主要结局
Performance on a Reality monitoring task and on an externalization task
时间窗: one day
A computerized source memory task was designed for this study and a computerized externalization task was also designed (see description above). Rate of correct responses in both tasks is the main outcome.
次要结局
- Performance on a task measuring the impact of emotional stimuli on externalization processes(one day)
- Performance on source separating paradigms(one day)
- Performance on basic auditory tasks(one day)