Comparison of 2 different combination therapy in patients with Rheumatoid Arthritis failingMethotrexate monotherapy

Not Applicable

Completed

• Conditions: Health Condition 1: null- Rheumatoid arthritis

• Registration Number: CTRI/2016/11/007508
• Lead Sponsor: JIPMER Intramural fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-03-31
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 136

Inclusion Criteria

1.satisfying ACR-EULAR criteria for Rheumatoid arthritis

2.Polyarthritis ( >4 joints)

3.Disease duration of less than 2 years

4.DMARD naïve patients

5.Patients with moderate to severe disease activity (DAS28 >3.2)

Exclusion Criteria

1.End stage disease (deformed fixed joints)

2.Patients with vasculitis, extra-articular features like interstitial lung disease

3.Contraindications to DMARD therapy (Chronic Alcoholism, Chronic liver

disease, Evidence of acute/chronic infection, Chronic kidney disease,

Patients with leucopenia ( <3.0Ã?109/l), thrombocytopenia ( <150Ã?109/l),

AST/ALT >2Ã? upper normal value and creatinine clearance <30ml/minute )

4.Pregnant, lactating women, patients (both men and women) of reproductive age group unwilling for contraceptive use who have not completed the family

Study & Design

• Study Type: Interventional
• Study Design: Not specified