Neural Correlates of Self Body-shape Recognition in Anorexia Nervosa, an fMRI Activation Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Measure of the activation brain areas in self body-recognition network
研究概览
简要总结
Body Image distortion is a key diagnostic feature for Anorexia Nervosa. Patients suffering from Anorexia Nervosa tend to perceive themselves as fatter than they are. This bias might be at the origin of a reinforcement of anorectic behavior which might alter medical care. The objective of this study is to identify neural correlates of self-recognition in Anorexia Nervosa. Patients are hypothesized to activate the self-recognition network when seeing images of a fatter body shape than their own.
详细描述
Patients suffering from Anorexia Nervosa and control subjects (matched by age and study level) are recruited in medical care facilities in Lille's Metropolis. They are asked to identify their body shape when being presented with 3 different stimuli, i.e.real (RBS), estimated (EBS) and neutral body shape (NBS), in a functional magnetic resonance imaging or functional MRI (fMRI) machine. While answering to this identification paradigm, we hoped to identify modifications in the self body-recognition network.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 45 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Providing informed, dated and signed consent (for minors, consent must be signed by both parents)
- •With medical insurance
- •With normal vision
- •Only for the AN Group : Diagnosis of Anorexia Nervosa (AN) restrictive for at least one year and with a Body Masse index (BMI) between 14 and 18
- •Only for the control Group : BMI between 18 and 25 and without any psychiatric disorder
排除标准
- •Pregnant or breast-feeding women
- •With antecedent or current neurologic disease
- •With antecedent or current ophthalmologic disease
- •Contraindication for IRMf
结局指标
主要结局
Measure of the activation brain areas in self body-recognition network
时间窗: 15 days
Level of activation areas in the self body-recognition network measured during fMRI
次要结局
未报告次要终点